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MEF2C and PLA2G12A
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
MEF2C
PLA2G12A
Description
myocyte enhancer factor 2C
phospholipase A2 group XIIA
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sarcoplasm
Nuclear Speck
Protein-containing Complex
Postsynapse
Extracellular Region
Cytoplasm
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Hydrolase Activity
Metal Ion Binding
Calcium-dependent Phospholipase A2 Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Blood Vessel Development
Osteoblast Differentiation
Neuron Migration
B Cell Homeostasis
Heart Looping
Endochondral Ossification
Blood Vessel Remodeling
Chondrocyte Differentiation
Germinal Center Formation
Regulation Of Germinal Center Formation
Response To Ischemia
Primary Heart Field Specification
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Sinoatrial Valve Morphogenesis
Cardiac Ventricle Formation
Regulation Of DNA-templated Transcription
Apoptotic Process
Humoral Immune Response
Nervous System Development
Heart Development
Muscle Organ Development
Skeletal Muscle Tissue Development
Muscle Cell Fate Determination
Learning Or Memory
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Neural Crest Cell Differentiation
Myotube Differentiation
Cell Differentiation
Neuron Differentiation
Platelet Formation
Negative Regulation Of Ossification
Melanocyte Differentiation
Positive Regulation Of Bone Mineralization
Positive Regulation Of B Cell Proliferation
Cellular Response To Trichostatin A
B Cell Proliferation
Positive Regulation Of MAPK Cascade
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurotransmitter Secretion
Regulation Of Synaptic Plasticity
Positive Regulation Of Skeletal Muscle Tissue Development
Neuron Development
Cell Morphogenesis Involved In Neuron Differentiation
B Cell Receptor Signaling Pathway
Smooth Muscle Cell Differentiation
Regulation Of Synapse Assembly
Regulation Of Synaptic Transmission, Glutamatergic
Ventricular Cardiac Muscle Cell Differentiation
Regulation Of Synaptic Activity
Positive Regulation Of Cardiac Muscle Cell Proliferation
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Development
Renal Tubule Morphogenesis
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Glomerulus Morphogenesis
Nephron Tubule Epithelial Cell Differentiation
NMDA Selective Glutamate Receptor Signaling Pathway
AMPA Selective Glutamate Receptor Signaling Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Cardiac Muscle Cell Differentiation
Positive Regulation Of Behavioral Fear Response
Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Positive Regulation Of Skeletal Muscle Cell Differentiation
Lipid Metabolic Process
Phospholipid Metabolic Process
Lipid Catabolic Process
Arachidonate Secretion
Pathways
ERK/MAPK targets
Transcriptional activation of mitochondrial biogenesis
Myogenesis
MECP2 regulates transcription factors
Heme signaling
Cardiogenesis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Accelerometer-based physical activity measurement (average acceleration) (
29899525
)
Adult body size (
32376654
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Attention deficit hyperactivity disorder (
29325848
)
Bipolar disorder lithium response (categorical) or schizophrenia (
29121268
)
Body mass index (
26426971
)
Bone mineral density (
23572186
24249740
21533022
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (total hip) (
29883787
)
Bone mineral density (Ward's triangle area) (
27397699
)
Caffeine consumption from coffee (
33287642
)
Chronotype (
30696823
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Depression (
29700475
)
Femoral neck bone mineral density (
32239398
29499414
22504420
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
General cognitive ability (
29844566
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Height (
20881960
25282103
25429064
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Household income (MTAG) (
31844048
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Lamb consumption (
32066663
)
Lymphocyte percentage of white cells (
32888494
)
Major depressive disorder (
27479909
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
27863252
22139419
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Morning person (
30696823
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Photic sneeze reflex (
27182965
)
Platelet count (
32888494
27863252
22139419
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Red blood cell count (
27863252
32888494
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Retinal arteriolar caliber (
23776548
)
Retinal vascular caliber (
21060863
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
25056061
30285260
)
Serum alkaline phosphatase levels (
33547301
)
Smoking status (ever vs never smokers) (
30643258
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Tonometry (
17903302
)
Vascular endothelial growth factor levels (
26910538
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for body mass index (
28448500
)
HDL cholesterol (
30275531
)
Lipoprotein (a) levels (
33730874
)
Mean spheric corpuscular volume (
32888494
)
Triglycerides (
30275531
)
Interacting Genes
31 interacting genes:
ASCL1
CCNB1
CDK1
COPS5
CSNK2A1
EP300
EPAS1
GATA4
HDAC4
HDAC5
HDAC7
HDAC9
KPNA4
MAPK14
MAPK7
MEF2D
MYOD1
MYOG
NCOA2
NOTCH1
PLA2G12A
SMAD2
SOX18
SP1
SPTBN1
TEAD1
TWIST2
UBE2I
VGLL2
VGLL4
YWHAZ
8 interacting genes:
DVL2
MEF2C
RB1
RPS15
RPS6
TMEM37
UMPS
YWHAG
Entrez ID
4208
81579
HPRD ID
02809
17858
Ensembl ID
ENSG00000081189
ENSG00000123739
Uniprot IDs
A0A0D9SFD0
A0A0D9SGI5
A0A0R4J2G5
A0A9L9PYA3
D8L7E9
Q06413
Q542Y6
Q9BZM1
PDB IDs
Enriched GO Terms of Interacting Partners
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Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Myotube Differentiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Striated Muscle Cell Differentiation
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Nucleoplasm
DNA-binding Transcription Activator Activity
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cell Fate Commitment
Histone Deacetylase Activity, Hydrolytic Mechanism
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Nucleus
Regulation Of Developmental Process
Striated Muscle Tissue Development
Protein Lysine Deacetylase Activity
Negative Regulation Of Metabolic Process
Chromatin
Regulation Of Cardiac Muscle Cell Proliferation
Muscle Tissue Development
Regulation Of Muscle Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Histone Deacetylase Activity
Heart Development
DNA-binding Transcription Factor Activity
Ribosomal Small Subunit Assembly
Cytoplasmic Translation
Cell Morphogenesis Involved In Neuron Differentiation
Response To Insulin
Small Ribosomal Subunit
Positive Regulation Of Signal Transduction By P53 Class Mediator
Response To Hormone
Cytosolic Small Ribosomal Subunit
Outflow Tract Morphogenesis
Heart Looping
Embryonic Heart Tube Morphogenesis
Chondrocyte Differentiation
Striated Muscle Cell Differentiation
Cellular Response To Oxygen-containing Compound
Cellular Response To Hormone Stimulus
Cellular Response To Xenobiotic Stimulus
Sinoatrial Valve Morphogenesis
Heart Valve Morphogenesis
Negative Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Ribosomal Small Subunit Biogenesis
Translation
Orotidine-5'-phosphate Decarboxylase Activity
Orotate Phosphoribosyltransferase Activity
Intracellular Signal Transduction
Negative Regulation Of Kinase Activity
TOR Signaling
Muscle Cell Fate Determination
Nephron Tubule Epithelial Cell Differentiation
Cellular Response To Trichostatin A
Cellular Response To Insulin Stimulus
Cytosolic Ribosome
Positive Regulation Of Intracellular Signal Transduction
Muscle Cell Differentiation
Negative Regulation Of Protein Phosphorylation
Epithelial Tube Morphogenesis
Convergent Extension Involved In Neural Plate Elongation
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Macrophage Apoptotic Process
Primary Heart Field Specification
Glomerulus Morphogenesis
Negative Regulation Of Phosphorylation
Chromatin Lock Complex
'de Novo' UMP Biosynthetic Process
Protein Kinase C Inhibitor Activity
Osteoblast Differentiation
Cytosol
Regulation Of Synaptic Activity
Sister Chromatid Biorientation
Maintenance Of Mitotic Sister Chromatid Cohesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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