RAB38

Description		RAB38, member RAS oncogene family
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GO Annotations	Cellular Component	Mitochondrion Lysosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Lumen Vesicle Melanosome Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Body Phagocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Mitochondrion Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Melanin Biosynthetic Process Platelet Dense Granule Organization Protein Localization To Membrane Phagosome Acidification Melanosome Assembly Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Chloride levels ( 29403010) Frontotemporal dementia ( 24943344) Gut microbiota (bacterial taxa) ( 27694959) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis (age of onset) ( 19010793) Sodium levels ( 29403010) Triiodothyronine levels ( 30824882) Urinary albumin-to-creatinine ratio in diabetes ( 26631737)
Interacting Genes		7 interacting genes: APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 TGFBR1
Entrez ID		23682
HPRD ID		05889
Ensembl ID		ENSG00000123892
Uniprot IDs		P57729
PDB IDs		6HDU 6S5H
Enriched GO Terms of Interacting Partners?		I-SMAD Binding SMAD Protein Complex Response To Growth Factor Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Pattern Specification Process Trophoblast Cell Migration SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gene Expression Co-SMAD Binding Response To Transforming Growth Factor Beta Regulation Of Cartilage Development Primary MiRNA Processing Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regionalization Regulation Of MiRNA Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Extracellular Matrix Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Developmental Growth Osteoblast Differentiation Ameboidal-type Cell Migration R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of RNA Metabolic Process Homomeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Cartilage Development Endoderm Development MiRNA Processing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification
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