AKR1B1

Gene Name		aldo-keto reductase family 1, member B1 (aldose reductase)
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Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Electron Carrier Activity Glyceraldehyde Oxidoreductase Activity
	Biological Process	Carbohydrate Metabolic Process C21-steroid Hormone Biosynthetic Process Response To Stress Steroid Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Oxidation-reduction Process
Pathways		Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Metabolism of steroid hormones and vitamin D
Drugs		NADH Sulindac Inhibitor Idd 384 Alpha-D-Glucose-6-Phosphate Alrestatin Fidarestat Fidarestat(Stereoisomer) [3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid Tolrestat N-Acetylalanine Sorbinil IDD552 Hydroxydimethylarsine Oxide 2\'-Monophosphoadenosine 5\'-Diphosphoribose Citric Acid (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3\'-PYRROLIDINE]-1,2\',3,5\'(2H)-TETRONE 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE IDD594 {[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Diseases
GWAS
Protein-protein Interactions		2 interactors: SHBG SMAD1
Entrez ID		231
HPRD ID		00071
Ensembl ID		ENSG00000085662
Uniprot IDs		P15121
PDB IDs		1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU 3LBO 3LD5 3LEN 3LEP 3LQG 3LQL 3LZ3 3LZ5 3M0I 3M4H 3M64 3MB9 3MC5 3ONB 3ONC 3P2V 3Q65 3Q67 3RX2 3RX3 3RX4 3S3G 3T42 3U2C 3V35 3V36 3V9Q 4GCA
Enriched GO Terms of Interacting Partners?		Primary Spermatocyte Growth Growth Primary MiRNA Processing Osteoblast Fate Commitment Gamete Generation SMAD Protein Complex Assembly Sexual Reproduction Multicellular Organismal Reproductive Process Mesodermal Cell Fate Commitment Multicellular Organism Reproduction Cardiac Muscle Cell Proliferation Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To BMP Stimulus Reproduction Mesodermal Cell Differentiation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Muscle Tissue Growth Single Organism Reproductive Process Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Dendrite Morphogenesis Gene Silencing By MiRNA Cellular Response To DsRNA Reproductive Process Positive Regulation Of Cartilage Development Posttranscriptional Gene Silencing Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Gene Silencing By RNA Regulation Of Dendrite Morphogenesis Positive Regulation Of Osteoblast Differentiation Response To DsRNA BMP Signaling Pathway Midbrain Development Mesoderm Formation Developmental Cell Growth Regulation Of Cartilage Development Embryonic Pattern Specification Mesoderm Morphogenesis Positive Regulation Of Ossification Organ Growth Regulation Of Dendrite Development Gene Silencing Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Osteoblast Differentiation
Tagcloud ?		11beta 9alpha abcc4 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases