MAPK10 and JUN

Number of citations of the paper that reports this interaction (PubMedID 12167088)
33

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MAPK10	JUN
Description		mitogen-activated protein kinase 10	Jun proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade Response To Light Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Microglial Cell Activation Liver Development Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway JNK Cascade Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Epithelial Cell Migration Release From Viral Latency Monocyte Differentiation Axon Regeneration Response To Endoplasmic Reticulum Stress Leading Edge Cell Differentiation Response To Muscle Stretch Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Response To Steroid Hormone Regulation Of Cell Cycle SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Anisomycin Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants Regulation of PD-L1(CD274) transcription
Drugs		Minocycline Pyrazolanthrone Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Fostamatinib Halicin	Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Cobalt levels ( 26025379) Diisocyanate-induced asthma ( 25918132) Gait speed in old age ( 28077804) Liver enzyme levels (alanine transaminase) ( 22001757 33972514) Multiple sclerosis ( 31604244) Peripheral artery disease ( 25009551) Response to cytidine analogues (gemcitabine) ( 24483146) Triglyceride levels ( 32154731 32203549)	Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)
Interacting Genes		40 interacting genes: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 DUSP9 ELK1 FBXO7 GTF3C1 HAX1 HDAC9 HNRNPK HRAS JUN KIF26A KIF5A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MAPT MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UBE3A UNC119	181 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GGA1 GGA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MECOM MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C
Entrez ID		5602	3725
HPRD ID		04207	01302
Ensembl ID		ENSG00000109339	ENSG00000177606
Uniprot IDs		A0A286YEQ0 A0A286YF97 D6RJF9 F8W9R5 P53779 Q499Y8	P05412
PDB IDs		1JNK 1PMN 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B 4KKE 4KKG 4KKH 4U79 4W4V 4W4W 4W4X 4W4Y 4WHZ 4X21 4Y46 4Y5H 4Z9L 6EKD 6EMH 6EQ9 7KSI 7KSJ 7KSK 7ORE 7ORF 7S1N 7YL1 8BZP 8ENJ 8VNX 8VO4 8VS0 8VTF 8WGF	1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V 8SOS
Enriched GO Terms of Interacting Partners?		Cytoplasm Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Neuron Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling JUN Kinase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Nucleus Regulation Of Apoptotic Process MAPK Cascade Regulation Of Programmed Cell Death Cytosol Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding JNK Cascade MAP Kinase Tyrosine Phosphatase Activity Cellular Senescence Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Tyrosine/threonine Phosphatase Activity Protein Kinase Binding Programmed Cell Death Regulation Of Growth Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Post-translational Protein Modification Negative Regulation Of Multicellular Organismal Process Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Post-translational Protein Modification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription General Transcription Initiation Factor Binding Nucleoplasm Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Regulation Of Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription By RNA Polymerase II Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Developmental Process Intracellular Signaling Cassette DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process
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