TM4SF1 and TUBA4A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TM4SF1	TUBA4A
Gene Name		transmembrane 4 L six family member 1	tubulin, alpha 4a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome
	Molecular Function	Molecular_function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Biological_process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways			Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ANPEP DDR1 DNAJA1 HSPA8 SDCBP2 TUBA4A	49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		4071	7277
HPRD ID		01854	01851
Ensembl ID		ENSG00000169908	ENSG00000127824
Uniprot IDs		P30408	A8MUB1 P68366
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Refolding Protein Folding 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Locomotion Negative Regulation Of Fibril Organization Response To Heat Secretion Response To Unfolded Protein Smooth Muscle Cell-matrix Adhesion Regulation Of Fibril Organization Response To Temperature Stimulus Cellular Protein Metabolic Process Clathrin Coat Disassembly Cellular Localization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Stimulus Collagen-activated Signaling Pathway Transport DNA Damage Response, Detection Of DNA Damage Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of JUN Kinase Activity Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Movement Of Cell Or Subcellular Component Chaperone Mediated Protein Folding Requiring Cofactor Wound Healing, Spreading Of Cells Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Extracellular Matrix Organization Response To Stress Muscle Cell Migration Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Secretion By Cell Mammary Gland Lobule Development Mammary Gland Alveolus Development Positive Regulation Of RNA Splicing Viral Process Regulation Of Cellular Response To Heat Cellular Response To Stimulus Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of JNK Cascade Regulation Of Body Fluid Levels Wound Healing Peptide Hormone Processing Negative Regulation Of Stress-activated MAPK Cascade Peptidyl-tyrosine Autophosphorylation Establishment Of Localization In Cell	Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		a549 adenocarcinoma ag almost blocking calu clearly consequently homologs igf1 igf1r l6 lung member mesenchymal migration overexpressing pten radiotherapy slightly tetraspanin therapeutics transmembrane tumorigenic unlike upregulated xenograft	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Difference) ?		a549 adenocarcinoma ag almost blocking calu clearly consequently homologs igf1 igf1r l6 lung member mesenchymal migration overexpressing pten radiotherapy slightly tetraspanin therapeutics transmembrane tumorigenic unlike upregulated xenograft	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Intersection) ?