TM4SF1 and DDR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TM4SF1	DDR1
Description		transmembrane 4 L six family member 1	discoidin domain receptor tyrosine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Blastocyst Formation	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways			Non-integrin membrane-ECM interactions
Drugs			Imatinib Fostamatinib Pralsetinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: ANPEP DDR1 DNAJA1 HSPA8 SDCBP2 SLC13A1 TUBA4A	20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		4071	780
HPRD ID		01854	02678
Ensembl ID		ENSG00000169908	ENSG00000204580
Uniprot IDs		F8WF27 P30408	A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs			3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Extracellular Exosome ATPase Activator Activity MHC Class II Protein Complex Binding Protein Refolding Protein-macromolecule Adaptor Activity Alanyl Aminopeptidase Activity Protein Transport Into Plasma Membrane Raft Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Response To Unfolded Protein G Protein-coupled Receptor Binding Heat Shock Protein Binding Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Lumenal Side Of Lysosomal Membrane Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K8ac Reader Activity Histone H4K12ac Reader Activity Protein-folding Chaperone Binding Unfolded Protein Binding Regulation Of Protein Import Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Sodium Ion Transmembrane Transport Protein Transport Into Membrane Raft Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy P-TEFb Complex Binding Histone H4 Reader Activity Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Clathrin Coat Disassembly Histone H4K16ac Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane P-type Sodium:potassium-exchanging Transporter Activity ATP Metabolic Process Sodium Ion Transport Regulation Of Potassium Ion Import Negative Regulation Of JUN Kinase Activity Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Secondary Active Sulfate Transmembrane Transporter Activity RNA Polymerase II C-terminal Domain Binding	Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction
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