MIR92A2 and TRIM25

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR92A2	TRIM25
Description		microRNA 92a-2	tripartite motif containing 25
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function		Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress MRNA Transcription Protein Ubiquitination Viral Release From Host Cell Regulation Of Protein Localization Response To Vitamin D Cellular Response To Oxidative Stress ERAD Pathway RIG-I Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K48-linked Ubiquitination Antiviral Innate Immune Response Cellular Response To Leukemia Inhibitory Factor
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		88 interacting genes: ADARB1 AIMP2 AQR C1QBP CELF1 CPSF1 CPSF2 CPSF3 CPSF4 CSTF1 CSTF2 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FIP1L1 FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBM14 RBM4 RBMS1 RBMS2 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2B TRIM25 UPF1 UTP20 WDR33 YBX1 YBX3 ZC3H7A ZNF346	77 interacting genes: AMFR APC CASP7 CEBPA CHKA CRK DDX3X DICER1 EIF4G3 ERCC2 ERG ESR1 G3BP1 G3BP2 GABARAP GABARAPL1 GABARAPL2 GATA1 GRIK2 LINC00955 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PIK3R1 PITX2 PLAAT4 PTEN RBCK1 RIPK3 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZBTB7A ZNF24
Entrez ID		407049	7706
HPRD ID			02711
Ensembl ID		ENSG00000284538	ENSG00000121060
Uniprot IDs			Q14258
PDB IDs			4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing RNA Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Nucleus MRNA Binding Nucleoplasm Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA Binding Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Regulation Of MRNA Processing Regulation Of RNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation Regulation Of MRNA Stability Ligase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA 3'-end Processing MRNA Stabilization Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process MiRNA Processing Positive Regulation Of Gene Expression CRD-mediated MRNA Stabilization Nucleolus Regulation Of Gene Expression MRNA 5'-UTR Binding	Post-transcriptional Gene Silencing RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nitrogen Starvation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Phosphatidylethanolamine Binding Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MRNA 3'-UTR Binding Cellular Response To Stress Negative Regulation Of Gene Expression Post-translational Protein Modification Response To Stress Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Translation Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Locomotion
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