LY6E and GPAA1

Data Source: HiPPIP (Novel)

		LY6E	GPAA1
Name		lymphocyte antigen 6 family member E	glycosylphosphatidylinositol anchor attachment 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Synapse Side Of Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	Protein Binding Acetylcholine Receptor Inhibitor Activity Acetylcholine Receptor Binding	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Host-mediated Suppression Of Symbiont Invasion Acetylcholine Receptor Signaling Pathway	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Attachment of GPI anchor to uPAR
GWAS		No GWAS studies recorded	Asthma ( 31959851 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 )
Novel Interactors		8 novel interactors: AKR1B1 EIF3H GLI4 GML GPAA1 HSF1 JRK PIP	9 novel interactors: ADAMDEC1 CACNG8 DGAT1 GIT1 LRRC14 LY6E NDRG1 TERF2IP TONSL
Interacting Genes		6 interacting genes: CD247 FCGR2B MFSD6 TMEM140 TMEM19 TRARG1	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		4061	8733
HPRD ID		03227	04334
Ensembl ID		ENSG00000160932	ENSG00000197858
Uniprot IDs		Q16553	O43292
PDB IDs		Not available	7W72 7WLD 8IMX 8IMY
GO Terms Enriched among Interactors		IgG Binding	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process