LATS2 and MOB3A

Number of citations of the paper that reports this interaction (PubMedID 19739119)
0

Data Source:
BioGRID (pull down)

		LATS2	MOB3A
Description		large tumor suppressor kinase 2	MOB kinase activator 3A
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Centriolar Satellite	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase Activator Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Signal Transduction
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Interacting Genes		70 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DCAF1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NFIC PDGFRA RAF1 RASSF1 RELA SIAH2 SMAD2 SNAI1 SRC STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ	7 interacting genes: APP FBXO7 LATS1 LATS2 NEDD4 NEDD4L TGIF1
Entrez ID		26524	126308
HPRD ID		07277	17583
Ensembl ID		ENSG00000150457	ENSG00000172081
Uniprot IDs		Q9NRM7	Q96BX8
PDB IDs		4ZRI
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Signal Transduction Regulation Of Cell Population Proliferation Animal Organ Development Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Phosphorylation Protein Modification Process Regulation Of Protein Modification Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Transferase Activity Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Protein Localization Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Developmental Process Negative Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Synapse Organization Regulation Of Developmental Growth Sodium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Potassium Channel Inhibitor Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus Receptor Catabolic Process Positive Regulation Of Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Growth Hippo Signaling Regulation Of Cellular Component Organization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Protein Metabolic Process Neuromuscular Junction Development Regulation Of Canonical Wnt Signaling Pathway Synapse Organization Ubiquitin-protein Transferase Activity Regulation Of Monoatomic Cation Transmembrane Transport Cellular Developmental Process Protein Modification Process Protein Metabolic Process Protein Polyubiquitination Regulation Of Hippo Signaling Receptor Metabolic Process Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Monoatomic Ion Transmembrane Transport
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