LATS2 and HGF

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		LATS2	HGF
Description		large tumor suppressor kinase 2	hepatocyte growth factor
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Centriolar Satellite	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Proteolysis Signal Transduction Negative Regulation Of Autophagy Skeletal Muscle Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Animal Organ Development Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Chemotaxis Regulation Of Multicellular Organismal Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by Hippo	Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 Drug-mediated inhibition of MET activation
Drugs			Valproic acid Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)	Blood protein levels ( 30072576) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Gout (normal type) ( 32238385) Hepatocyte growth factor levels ( 25998175 27989323) Intraocular pressure ( 29235454 29785010) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)
Interacting Genes		70 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DCAF1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NFIC PDGFRA RAF1 RASSF1 RELA SIAH2 SMAD2 SNAI1 SRC STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ	36 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG
Entrez ID		26524	3082
HPRD ID		07277	00799
Ensembl ID		ENSG00000150457	ENSG00000019991
Uniprot IDs		Q9NRM7	P14210
PDB IDs		4ZRI	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3 7MO7 7MO8 7MO9 7MOA 7MOB 7OCL 7OCM
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Signal Transduction Regulation Of Cell Population Proliferation Animal Organ Development Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Phosphorylation Protein Modification Process Regulation Of Protein Modification Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Transferase Activity Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Protein Kinase Activity Negative Regulation Of Multicellular Organismal Process Kinase Activity Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction Cellular Developmental Process Developmental Process Cell Differentiation Regulation Of Fibrinolysis Animal Organ Development Negative Regulation Of Blood Coagulation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Process Serine-type Peptidase Activity Regulation Of Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Serine-type Endopeptidase Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Zymogen Activation Positive Regulation Of Biosynthetic Process Plasminogen Activation Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Maturation Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Motility Protein Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Plasminogen Activation Regulation Of Cell-substrate Adhesion Enzyme-linked Receptor Protein Signaling Pathway
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