LATS2 and MOB3B

Number of citations of the paper that reports this interaction (PubMedID 19739119)
0

Data Source:
BioGRID (pull down)

		LATS2	MOB3B
Description		large tumor suppressor kinase 2	MOB kinase activator 3B
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Centriolar Satellite	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Activator Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Signal Transduction Regulation Of Hippo Signaling
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)	Adult asthma ( 27611488) Asthma ( 27611488) Delirium ( 29631748) Plasma trimethylamine N-oxide levels ( 28439531) Urinary symptoms in response to radiotherapy in prostate cancer ( 23376709)
Interacting Genes		70 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DCAF1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NFIC PDGFRA RAF1 RASSF1 RELA SIAH2 SMAD2 SNAI1 SRC STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ	6 interacting genes: LATS1 LATS2 MAPK14 NT5C2 PPBP STK3
Entrez ID		26524	79817
HPRD ID		07277	14728
Ensembl ID		ENSG00000150457	ENSG00000120162
Uniprot IDs		Q9NRM7	Q86TA1
PDB IDs		4ZRI
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Signal Transduction Regulation Of Cell Population Proliferation Animal Organ Development Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Phosphorylation Protein Modification Process Regulation Of Protein Modification Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Transferase Activity Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Hippo Signaling Regulation Of Organ Growth Positive Regulation Of Hippo Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Developmental Growth Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Transferase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Nucleus Protein Kinase Activity Spindle Pole Cell Morphogenesis Regulation Of Growth D-glucose Transmembrane Transport Kinase Activity ATP Binding Hexose Transmembrane Transport Canonical Inflammasome Complex Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Protein Metabolic Process Carbohydrate Transmembrane Transport Protein Modification Process Carbohydrate Transport Negative Regulation Of Protein Localization To Nucleus Regulation Of NLRP3 Inflammasome Complex Assembly Nucleotide Binding Protein Phosphorylation Negative Regulation Of Cell Cycle Keratinocyte Differentiation Positive Regulation Of Fat Cell Differentiation Phosphorylation Negative Regulation Of Protein Kinase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Negative Regulation Of Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Epidermal Cell Differentiation Canonical Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation
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