LORICRIN and EVPL

Number of citations: 0 (PubMedID 8999895)
Data Source: HPRD (in vivo)

		LORICRIN	EVPL
Name		loricrin cornified envelope precursor protein	envoplakin
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Structural Molecule Activity Cadherin Binding
	Biological Process	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Keratinization	Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Formation of the cornified envelope
Diseases		Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis	None
GWAS		No GWAS studies recorded	Deep white matter hyperintensities ( 32517579 ) Depressive symptom improvement ( 30468137 ) L-selectin levels ( 25576479 ) Metabolite levels ( 23823483 ) Periventricular white matter hyperintensities ( 32517579 )
Interacting Genes		8 interacting genes: CSTA EVPL IVL KRT1 PI3 SLC26A4-AS1 SPRR3 VIM	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		4014	2125
HPRD ID		01070	03352
Ensembl ID		ENSG00000203782	ENSG00000167880
Uniprot IDs		P23490	B7ZLH8 K7EKI0 Q92817
PDB IDs		Not available	4QMD
GO Terms Enriched among Interactors		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Epidermis Development Intermediate Filament Endopeptidase Inhibitor Activity Intermediate Filament Cytoskeleton Protein Modification Process Structural Constituent Of Skin Epidermis Wound Healing Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Organization Copulation Extracellular Exosome Peptidase Inhibitor Activity Peptidase Inhibitor Complex Cell Differentiation Cytosol Regulation Of Antibacterial Peptide Production Keratin Filament Binding Structural Molecule Activity Tissue Development Lens Fiber Cell Development Response To Wounding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Cellular Developmental Process Protein Metabolic Process Regulation Of Antimicrobial Humoral Response Complement Activation, Lectin Pathway Humoral Immune Response Protein Heterotetramerization	Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion