LORICRIN and PI3

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
BioGRID (pull down)

		LORICRIN	PI3
Description		loricrin cornified envelope precursor protein	peptidase inhibitor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis Peptidase Inhibitor Activity
	Biological Process	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Keratinization	Copulation Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Antimicrobial peptides Formation of the cornified envelope
Drugs
Diseases		Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Malaria ( 31844061)
Interacting Genes		8 interacting genes: CSTA EVPL IVL KRT1 PI3 SLC26A4-AS1 SPRR3 VIM	5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN
Entrez ID		4014	5266
HPRD ID		01070	15947
Ensembl ID		ENSG00000203782	ENSG00000124102
Uniprot IDs		P23490	P19957
PDB IDs			1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Epidermis Development Intermediate Filament Endopeptidase Inhibitor Activity Intermediate Filament Cytoskeleton Protein Modification Process Structural Constituent Of Skin Epidermis Wound Healing Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Organization Copulation Extracellular Exosome Peptidase Inhibitor Activity Peptidase Inhibitor Complex Cell Differentiation Cytosol Regulation Of Antibacterial Peptide Production Keratin Filament Binding Structural Molecule Activity Tissue Development Lens Fiber Cell Development Response To Wounding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Cellular Developmental Process Protein Metabolic Process Regulation Of Antimicrobial Humoral Response Complement Activation, Lectin Pathway Humoral Immune Response Protein Heterotetramerization	Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Protein Metabolic Process Protein Modification Process Cytoskeleton Organization Structural Constituent Of Skin Epidermis Epithelial Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Macromolecule Metabolic Process Developmental Process Elastin Catabolic Process Pancreas Morphogenesis Epidermis Development Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate Filament Peptidase Inhibitor Complex Cellular Response To Progesterone Stimulus Elastin Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Antibacterial Peptide Production Regulation Of Defense Response Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Dephosphorylation Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Signal Complex Assembly Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Signaling Receptor Activator Activity Cell Differentiation Exocrine Pancreas Development Digestive System Development Regulation Of Antimicrobial Humoral Response Regulation Of Immune Response Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Lamellipodium Morphogenesis Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Positive Regulation Of Integrin Activation Phospholipase Activator Activity
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