LMX1A and BMPR2

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		LMX1A	BMPR2
Gene Name		LIM homeobox transcription factor 1, alpha	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Zinc Ion Binding Sequence-specific DNA Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Axon Guidance Dentate Gyrus Development Cerebellum Development Central Nervous System Neuron Differentiation Midbrain Development Negative Regulation Of Neuron Differentiation Dopaminergic Neuron Differentiation	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		Response to acetaminophen (hepatotoxicity) ( 21177773)	Urate levels ( 23263486)
Protein-Protein Interactions		5 interactors: BMPR2 ISL1 LDB1 LHX3 TCF3	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		4009	659
HPRD ID		02623	02880
Ensembl ID		ENSG00000162761	ENSG00000204217
Uniprot IDs		Q8TE12	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Brain Development Head Development Transcription From RNA Polymerase II Promoter Central Nervous System Development Generation Of Neurons Neurogenesis Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Nervous System Development Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Cell Fate Commitment Stem Cell Differentiation Embryo Development Histone H3 Acetylation Organ Development Spinal Cord Motor Neuron Differentiation Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Pituitary Gland Development Ventral Spinal Cord Development Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Neuron Fate Commitment Regulation Of Neuron Differentiation Tissue Development Diencephalon Development Mesoderm Morphogenesis Cell Fate Specification Response To External Stimulus	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?