LMX1A and LHX3

Number of citations of the paper that reports this interaction (PMID 9452425)
36

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LMX1A	LHX3
Gene Name		LIM homeobox transcription factor 1, alpha	LIM homeobox 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Cell Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Axon Guidance Dentate Gyrus Development Cerebellum Development Central Nervous System Neuron Differentiation Midbrain Development Negative Regulation Of Neuron Differentiation Dopaminergic Neuron Differentiation	Placenta Development Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development
Pathways
Drugs
Diseases
GWAS		Response to acetaminophen (hepatotoxicity) ( 21177773)	Height ( 20189936) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		5 interactors: BMPR2 ISL1 LDB1 LHX3 TCF3	8 interactors: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM
Entrez ID		4009	8022
HPRD ID		02623	02783
Ensembl ID		ENSG00000162761	ENSG00000107187
Uniprot IDs		Q8TE12	F1T0D5 F1T0D7 F1T0D9 Q9UBR4
PDB IDs
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Brain Development Head Development Transcription From RNA Polymerase II Promoter Central Nervous System Development Generation Of Neurons Neurogenesis Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Nervous System Development Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Cell Fate Commitment Stem Cell Differentiation Embryo Development Histone H3 Acetylation Organ Development Spinal Cord Motor Neuron Differentiation Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Pituitary Gland Development Ventral Spinal Cord Development Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Neuron Fate Commitment Regulation Of Neuron Differentiation Tissue Development Diencephalon Development Mesoderm Morphogenesis Cell Fate Specification Response To External Stimulus	Central Nervous System Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Spinal Cord Development Axis Specification Central Nervous System Development Pattern Specification Process Visceral Motor Neuron Differentiation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Anatomical Structure Morphogenesis Brain Development Generation Of Neurons Head Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Organ Development Axon Guidance Peripheral Nervous System Neuron Development Cerebellum Development Left/right Axis Specification Metencephalon Development Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Cell Differentiation Cerebellar Purkinje Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Embryo Development Cell Projection Organization Cerebellar Purkinje Cell Layer Morphogenesis Axonogenesis Nervous System Development Transcription, DNA-templated Hindbrain Development Axon Development Left/right Pattern Formation Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Organ Morphogenesis RNA Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Negative Regulation Of Biosynthetic Process Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Cerebellar Cortex Formation
Tagcloud ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lim lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Difference) ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb1 ldb2 lhx lhx1 lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Intersection) ?		lim