ARHGDIG and KXD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ARHGDIG	KXD1
Description		Rho GDP dissociation inhibitor gamma	KxDL motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Lysosome Lysosomal Membrane Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex
	Molecular Function	GDP-dissociation Inhibitor Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Protein Binding
	Biological Process	Blastocyst Hatching Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Protein Localization	Vesicle-mediated Transport Lysosome Localization Regulation Of Endosome Size Regulation Of Lysosome Size Organelle Transport Along Microtubule
Pathways		RHOB GTPase cycle CDC42 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		12 interacting genes: AGTR1 BICRAL CDC42 CEP170P1 KXD1 MED10 RAC1 RHOA RHOB RHOG RHOH TACC3	42 interacting genes: APPL1 ARHGDIG C4orf46 CCDC185 CCDC33 CEP170P1 CEP19 CEP63 DYRK2 ELOA ELOA2 EWSR1 EXOC7 FXR2 GABARAPL1 HAUS1 IFT20 ING5 ITSN2 KRT81 LMO3 LNX1 LRRC45 MAB21L3 MAP1LC3A MAP1LC3B MCRS1 MOB1A MYH7 NIF3L1 NUDT18 RABGEF1 RNF183 RPL9 STX11 TCEA2 TPM1 TPM3 UTP6 ZBTB25 ZC4H2 ZNF417
Entrez ID		398	79036
HPRD ID		04163	14526
Ensembl ID		ENSG00000242173	ENSG00000105700
Uniprot IDs		F1T0H7 Q99819	Q9BQD3
PDB IDs
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction Actin Filament Organization GTPase Activity GTP Binding Rho Protein Signal Transduction Intracellular Signaling Cassette Supramolecular Fiber Organization Regulation Of Synapse Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Establishment Or Maintenance Of Cell Polarity Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Focal Adhesion Protein Kinase Binding Positive Regulation Of Actin Filament Bundle Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Postsynapse G Protein Activity Regulation Of Cytoskeleton Organization Thioesterase Binding Endothelial Tube Morphogenesis Regulation Of Stress Fiber Assembly Secretory Granule Membrane Regulation Of Modification Of Postsynaptic Structure Chemotaxis Establishment Of Epithelial Cell Apical/basal Polarity Intracellular Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion Angiotensin-activated Signaling Pathway Regulation Of Modification Of Synaptic Structure Actin Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Developmental Process Actin Filament-based Process Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Nuclear Migration Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Microtubule Cytoskeleton Organization Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Elongin Complex Muscle Thin Filament Tropomyosin Ciliary Basal Body Centrosome Transcription Elongation By RNA Polymerase II Cytoskeleton Protein Binding DNA-templated Transcription Elongation Autophagosome Maturation Autophagosome Membrane Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mitophagy Muscle Filament Sliding Spindle Pole
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