Wiki-Pi
About
Search
People
Updates
Search
ARHGDIG and RAC1
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
ARHGDIG
RAC1
Description
Rho GDP dissociation inhibitor gamma
Rac family small GTPase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Pericentriolar Material
Phagocytic Cup
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Cell Cortex
Membrane
Lamellipodium
Dendrite
Secretory Granule Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Ruffle Membrane
Cytoplasmic Ribonucleoprotein Granule
Melanosome
Presynaptic Membrane
Cell Projection
NADPH Oxidase Complex
Synapse
Postsynaptic Membrane
Recycling Endosome Membrane
Kinocilium
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Ficolin-1-rich Granule Membrane
Molecular Function
GDP-dissociation Inhibitor Activity
Rho GDP-dissociation Inhibitor Activity
GTPase Activator Activity
Protein Binding
GTPase Regulator Activity
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
Enzyme Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Thioesterase Binding
Protein-containing Complex Binding
Rho GDP-dissociation Inhibitor Binding
Biological Process
Blastocyst Hatching
Negative Regulation Of Cell Adhesion
Rho Protein Signal Transduction
Regulation Of Protein Localization
Neuron Migration
Positive Regulation Of Protein Phosphorylation
Auditory Receptor Cell Morphogenesis
Sphingosine-1-phosphate Receptor Signaling Pathway
Epithelial Cell Morphogenesis
Endocytosis
Phagocytosis, Engulfment
Inflammatory Response
Hyperosmotic Response
Cytoskeleton Organization
Actin Filament Organization
Cell Adhesion
Cell-matrix Adhesion
Establishment Or Maintenance Of Cell Polarity
Enzyme-linked Receptor Protein Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Axon Guidance
Motor Neuron Axon Guidance
Regulation Of Cell Shape
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Endothelial Cell Migration
Regulation Of Fibroblast Migration
Negative Regulation Of Fibroblast Migration
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Neuron Maturation
Dendrite Development
Cell Migration
Rac Protein Signal Transduction
Cerebral Cortex Radially Oriented Cell Migration
Embryonic Olfactory Bulb Interneuron Precursor Migration
Cerebral Cortex GABAergic Interneuron Development
Regulation Of Cell Morphogenesis
Cell Projection Assembly
Lamellipodium Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Polymerization
Cortical Cytoskeleton Organization
Forebrain Development
Positive Regulation Of Microtubule Polymerization
Ruffle Organization
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-23 Production
Regulation Of Actin Cytoskeleton Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Superoxide Anion Generation
Erythrocyte Enucleation
Engulfment Of Apoptotic Cell
Cell-cell Junction Organization
Regulation Of Nitric Oxide Biosynthetic Process
Respiratory Burst
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Hepatocyte Growth Factor Receptor Signaling Pathway
Regulation Of Neuronal Synaptic Plasticity
Negative Regulation Of Receptor-mediated Endocytosis
Anatomical Structure Arrangement
Neuron Projection Morphogenesis
Dendrite Morphogenesis
Cell Motility
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Localization Within Membrane
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Synaptic Transmission, GABAergic
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Respiratory Burst
Cell Chemotaxis
Positive Regulation Of Dendritic Spine Development
Regulation Of Cell Adhesion Involved In Heart Morphogenesis
Regulation Of ERK5 Cascade
Semaphorin-plexin Signaling Pathway
Dopaminergic Neuron Differentiation
Protein Localization To Plasma Membrane
Angiotensin-activated Signaling Pathway Involved In Heart Process
Positive Regulation Of Neutrophil Chemotaxis
Cochlea Morphogenesis
Ruffle Assembly
Regulation Of Postsynapse Assembly
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ruffle Assembly
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neutrophil Migration
Positive Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Interneuron Migration
Midbrain Dopaminergic Neuron Differentiation
Positive Regulation Of Ovarian Follicle Development
Regulation Of Neuron Migration
Pathways
RHOB GTPase cycle
CDC42 GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Nef and signal transduction
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
PCP/CE pathway
Sema4D mediated inhibition of cell attachment and migration
DCC mediated attractive signaling
DCC mediated attractive signaling
Activation of RAC1
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
RAC1 GTPase cycle
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Activation of RAC1 downstream of NMDARs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
WNT5:FZD7-mediated leishmania damping
Azathioprine ADME
Factors involved in megakaryocyte development and platelet production
Drugs
Dextromethorphan
Azathioprine
Guanosine-5'-Diphosphate
Diseases
GWAS
Body mass index (
26426971
)
Apolipoprotein A1 levels (
32203549
)
Basal cell carcinoma (
31174203
)
Body mass index (
26426971
)
Coronary artery disease (
29212778
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol levels (
32203549
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Red cell distribution width (
27863252
)
Interacting Genes
12 interacting genes:
AGTR1
BICRAL
CDC42
CEP170P1
KXD1
MED10
RAC1
RHOA
RHOB
RHOG
RHOH
TACC3
184 interacting genes:
ACTA1
ACTB
AGAP1
AGAP2
AKT1
ARAP1
ARAP2
ARFIP2
ARHGAP12
ARHGAP15
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP23
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP33
ARHGAP35
ARHGAP39
ARHGAP4
ARHGAP44
ARHGAP9
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF2
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF7
ARL2BP
BAG6
BAIAP2
BIRC2
BRINP1
CASP3
CASP7
CAV1
CDC23
CDC42BPG
CDC42SE1
CDC42SE2
CEBPA
CFAP36
CHN1
CHN2
CIT
COG5
CORO1C
CSN2
CYBA
CYBB
CYFIP1
DEF6
DIAPH1
DIAPH3
DMPK
DNMBP
DOCK1
DOCK2
DOCK3
DOCK7
DOCK8
DVL1
DVL2
EIF2AK2
ENAH
FAM13A
FAM13B
FGD5
FHOD1
FLNA
FMN2
FMNL1
GMIP
GRIA2
GRN
HACD3
HACE1
HDAC7
HPS4
ICMT
IFNGR1
IL1RAP
IQGAP1
IQGAP2
KPNA4
KPNA6
KRT40
KTN1
LATS1
LRP2
LTBP3
LTBP4
LZTS2
MAGI1
MAP3K10
MAP3K11
MAP3K4
MCF2
MCF2L
MCM3AP
MDFI
METAP2
MT-CO3
MTNR1A
MYD88
MYH9
NCF2
NCK1
NCKAP1
NEDD4
NME1
NOS2
NOXA1
NR2C2
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK5
PARD6A
PARD6B
PARD6G
PIAS3
PIK3R1
PIP4K2A
PLD1
PLEKHG1
PLEKHG2
PLEKHG6
PLXNA1
PLXNB1
PPP2R2B
PREX1
PREX2
PRKCA
PRKCD
PRKCI
PRKN
PRMT6
PTK2
RACGAP1
RALBP1
RAP1GDS1
RASGRF1
RASGRF2
RCC2
RGL2
RPS6KB1
SET
SFPQ
SH3BP1
SH3RF1
SH3RF3
SNCA
SNX31
SRGAP1
SRGAP3
STAT1
STAT3
STAU1
SYDE2
SYNJ2
TBC1D3F
TIAM1
TLR2
TNFRSF12A
TRIM72
TRIO
TUBA4A
UBC
UNKL
USH1C
USP6
VAV1
VAV2
VAV3
VWF
WAS
WASF1
Entrez ID
398
5879
HPRD ID
04163
03627
Ensembl ID
ENSG00000242173
ENSG00000136238
Uniprot IDs
F1T0H7
Q99819
A4D2P0
A4D2P1
P63000
PDB IDs
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
2YIN
3B13
3BJI
3RYT
3SBD
3SBE
3SU8
3SUA
3TH5
4GZL
4GZM
4YON
5FI0
5HZH
5N6O
5O33
5QQD
5QQE
5QQF
5QQG
5QQH
5QQI
5QQJ
5QQK
5QQL
5QQM
5QQN
5QU9
6AGP
6BC1
6TGC
6X1G
7AJK
7DPA
7SJ4
7USD
7USE
8I5V
8I5W
8Q0N
8WEJ
8ZJ2
8ZJI
8ZJJ
8ZJK
8ZJL
8ZJM
Enriched GO Terms of Interacting Partners
?
Small GTPase-mediated Signal Transduction
Actin Filament Organization
GTPase Activity
GTP Binding
Rho Protein Signal Transduction
Intracellular Signaling Cassette
Supramolecular Fiber Organization
Regulation Of Synapse Organization
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Establishment Or Maintenance Of Cell Polarity
Membrane Invagination
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Focal Adhesion
Protein Kinase Binding
Positive Regulation Of Actin Filament Bundle Assembly
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Postsynapse
G Protein Activity
Regulation Of Cytoskeleton Organization
Thioesterase Binding
Endothelial Tube Morphogenesis
Regulation Of Stress Fiber Assembly
Secretory Granule Membrane
Regulation Of Modification Of Postsynaptic Structure
Chemotaxis
Establishment Of Epithelial Cell Apical/basal Polarity
Intracellular Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Locomotion
Angiotensin-activated Signaling Pathway
Regulation Of Modification Of Synaptic Structure
Actin Cytoskeleton Organization
GTP-dependent Protein Binding
Establishment Of Apical/basal Cell Polarity
Regulation Of Actin Filament-based Process
Regulation Of Reactive Oxygen Species Metabolic Process
Polarized Epithelial Cell Differentiation
Regulation Of Postsynapse Organization
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Positive Regulation Of Developmental Process
Actin Filament-based Process
Rac Protein Signal Transduction
Positive Regulation Of Lamellipodium Assembly
Nuclear Migration
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Regulation Of Microtubule Cytoskeleton Organization
Establishment Of Epithelial Cell Polarity
Cerebral Cortex Cell Migration
Regulation Of Small GTPase Mediated Signal Transduction
GTPase Activator Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Small GTPase Binding
Intracellular Signaling Cassette
Signal Transduction
Small GTPase-mediated Signal Transduction
Intracellular Signal Transduction
Guanyl-nucleotide Exchange Factor Activity
Regulation Of Cellular Component Organization
Cytoplasm
Regulation Of Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Regulation Of Actin Cytoskeleton Organization
Plasma Membrane
Regulation Of Organelle Organization
Cell Cortex
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament Organization
Regulation Of Cell Projection Organization
Glutamatergic Synapse
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Rho Protein Signal Transduction
Actin Filament Organization
Cell Projection Organization
Regulation Of Anatomical Structure Morphogenesis
Supramolecular Fiber Organization
Regulation Of Developmental Process
Postsynapse
Regulation Of Synapse Organization
SH3 Domain Binding
Regulation Of Cell Morphogenesis
Positive Regulation Of Signaling
Cell Projection
Positive Regulation Of Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Cell Communication
Ruffle
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Cellular Component Organization
Plasma Membrane Bounded Cell Projection Organization
Lamellipodium
Regulation Of Cell Shape
Cell Migration
Regulation Of Biological Quality
Lamellipodium Organization
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?