ARHGDIG and RHOH

Number of citations of the paper that reports this interaction (PubMedID 11809807)
66

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ARHGDIG	RHOH
Description		Rho GDP dissociation inhibitor gamma	ras homolog family member H
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Immunological Synapse Cytoplasm Plasma Membrane Membrane
	Molecular Function	GDP-dissociation Inhibitor Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding
	Biological Process	Blastocyst Hatching Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Protein Localization	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation
Pathways		RHOB GTPase cycle CDC42 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	RHOH GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		12 interacting genes: AGTR1 BICRAL CDC42 CEP170P1 KXD1 MED10 RAC1 RHOA RHOB RHOG RHOH TACC3	23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1
Entrez ID		398	399
HPRD ID		04163	03616
Ensembl ID		ENSG00000242173	ENSG00000168421
Uniprot IDs		F1T0H7 Q99819	Q15669 Q6ICP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction Actin Filament Organization GTPase Activity GTP Binding Rho Protein Signal Transduction Intracellular Signaling Cassette Supramolecular Fiber Organization Regulation Of Synapse Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Establishment Or Maintenance Of Cell Polarity Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Focal Adhesion Protein Kinase Binding Positive Regulation Of Actin Filament Bundle Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Postsynapse G Protein Activity Regulation Of Cytoskeleton Organization Thioesterase Binding Endothelial Tube Morphogenesis Regulation Of Stress Fiber Assembly Secretory Granule Membrane Regulation Of Modification Of Postsynaptic Structure Chemotaxis Establishment Of Epithelial Cell Apical/basal Polarity Intracellular Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion Angiotensin-activated Signaling Pathway Regulation Of Modification Of Synaptic Structure Actin Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Developmental Process Actin Filament-based Process Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Nuclear Migration Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Microtubule Cytoskeleton Organization Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration	Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction
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