ARHGDIG and RHOB

Number of citations: 0 (PubMedID 8939998)
Data Source: HPRD (two hybrid)

		ARHGDIG	RHOB
Name		Rho GDP dissociation inhibitor gamma	ras homolog family member B
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	GDP-dissociation Inhibitor Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Blastocyst Hatching Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Protein Localization	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure
Pathways		RHOB GTPase cycle CDC42 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs		None	Botulinum toxin type A
GWAS		Body mass index ( 26426971 )	Systemic sclerosis ( 21750679 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Novel Interactors		None recorded	2 novel interactors: ADORA2A SNX17
Interacting Genes		12 interacting genes: AGTR1 BICRAL CDC42 CEP170P1 KXD1 MED10 RAC1 RHOA RHOB RHOG RHOH TACC3	18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5
Entrez ID		398	388
HPRD ID		04163	01321
Ensembl ID		ENSG00000242173	ENSG00000143878
Uniprot IDs		F1T0H7 Q99819	P62745
PDB IDs		Not available	2FV8 6HXU 6SGE
GO Terms Enriched among Interactors		Small GTPase-mediated Signal Transduction Actin Filament Organization GTPase Activity GTP Binding Rho Protein Signal Transduction Intracellular Signaling Cassette Supramolecular Fiber Organization Regulation Of Synapse Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Establishment Or Maintenance Of Cell Polarity Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Focal Adhesion Protein Kinase Binding Positive Regulation Of Actin Filament Bundle Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Postsynapse G Protein Activity Regulation Of Cytoskeleton Organization Thioesterase Binding Endothelial Tube Morphogenesis Regulation Of Stress Fiber Assembly Secretory Granule Membrane Regulation Of Modification Of Postsynaptic Structure Chemotaxis Establishment Of Epithelial Cell Apical/basal Polarity Intracellular Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion Angiotensin-activated Signaling Pathway Regulation Of Modification Of Synaptic Structure Actin Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Developmental Process Actin Filament-based Process Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Nuclear Migration Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Microtubule Cytoskeleton Organization Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration	Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation