ITGA3 and TIMP2

Number of citations of the paper that reports this interaction (PubMedID 16326706)
37

Data Source:
HPRD (in vivo)

		ITGA3	TIMP2
Description		integrin subunit alpha 3	TIMP metallopeptidase inhibitor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Growth Cone Filopodium Membrane Neuromuscular Junction Integrin Alpha3-beta1 Complex Cell Projection Receptor Complex Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Excitatory Synapse Extracellular Exosome Anchoring Junction Cell Periphery Synaptic Membrane Glutamatergic Synapse Growth Cone Filopodium	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Protease Binding Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Neuron Migration System Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Heart Development Memory Response To Xenobiotic Stimulus Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Cell Differentiation Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Skin Development Mesodermal Cell Differentiation System Development Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Cell-cell Adhesion Postsynapse Organization Synaptic Membrane Adhesion Positive Regulation Of Protein Localization To Plasma Membrane	Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity
Pathways		Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling	Activation of Matrix Metalloproteinases Neutrophil degranulation TGFBR3 PTM regulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		16 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 LINC00632 RABIF TIMP2 TSPAN4	6 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8 UBQLN2
Entrez ID		3675	7077
HPRD ID		05431	01784
Ensembl ID		ENSG00000005884	ENSG00000035862
Uniprot IDs		A0A140VJM0 P26006	A0A140VK57 P16035
PDB IDs			1BR9 1GXD 2TMP 4ILW
Enriched GO Terms of Interacting Partners?		Integrin Binding Focal Adhesion Protease Binding Calcium-independent Cell-matrix Adhesion Cell Surface Cell Activation Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Endothelial Cell Migration Protein-folding Chaperone Binding Positive Regulation Of Cell Migration Cell Migration Leukocyte Activation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Motility Laminin Binding Protein Maturation Extracellular Space Regulation Of Cell Motility Regulation Of Locomotion External Side Of Plasma Membrane Cell Motility Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Fusion Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Cellular Response To Low-density Lipoprotein Particle Stimulus Cell-substrate Adhesion Response To Muscle Activity Positive Regulation Of Endocytosis Cardiac Muscle Cell Differentiation Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Biological Process Involved In Interaction With Symbiont Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Cell Differentiation Cellular Component Assembly Regulation Of Neuron Differentiation B Cell Activation Positive Regulation Of Transport Lymphocyte Activation Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cardiocyte Differentiation Cell Adhesion	Fibronectin Binding Integrin Alpha3-beta1 Complex Endodermal Cell Differentiation Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vasoconstriction Metallopeptidase Activity Mesodermal Cell Differentiation Integrin Binding Serine-type Endopeptidase Activity Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Migration Laminin Binding Positive Regulation Of Cell Motility Regulation Of Protein Localization To Membrane Positive Regulation Of Locomotion Negative Regulation Of Rho Protein Signal Transduction Regulation Of Signal Transduction Integrin Complex Regulation Of Cell Communication Regulation Of Signaling Cell Migration Angiogenesis Ovarian Follicle Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Synaptic Membrane Cell Motility Regulation Of Vasoconstriction Response To Estrogen Positive Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Extracellular Matrix Positive Regulation Of Protein Localization To Cell Periphery Focal Adhesion Neuromuscular Junction Myoblast Fate Specification Response To Activity Integrin Alpha7-beta1 Complex Peptidase Activity Proteolysis Cellular Response To Genistein
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