ITGA3 and CD9

Number of citations: 0 (PubMedID 10065872)
Data Source: HPRD (in vitro, in vivo)

		ITGA3	CD9
Name		integrin subunit alpha 3	CD9 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Growth Cone Filopodium Membrane Neuromuscular Junction Integrin Alpha3-beta1 Complex Cell Projection Receptor Complex Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Excitatory Synapse Extracellular Exosome Anchoring Junction Cell Periphery Synaptic Membrane Glutamatergic Synapse Growth Cone Filopodium	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Integrin Binding Protein Binding
	Biological Process	Neuron Migration System Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Heart Development Memory Response To Xenobiotic Stimulus Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Cell Differentiation Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Skin Development Mesodermal Cell Differentiation System Development Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Cell-cell Adhesion Postsynapse Organization Synaptic Membrane Adhesion Positive Regulation Of Protein Localization To Plasma Membrane	Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Cell Differentiation Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration
Pathways		Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling	Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs		None	C31G
GWAS		No GWAS studies recorded	Colorectal cancer ( 24836286 ) Colorectal cancer or advanced adenoma ( 30510241 ) Mean platelet volume ( 22139419 27863252 32888494 ) Paclitaxel-induced neuropathy ( 23776197 ) Platelet count ( 22139419 26805783 )
Novel Interactors		None recorded	2 novel interactors: ATM CACNA1C
Interacting Genes		16 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 LINC00632 RABIF TIMP2 TSPAN4	25 interacting genes: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT ODF4 PRKCA PTGFRN SERPINH1 SLC22A1 SLC22A2 TSPAN4 VKORC1
Entrez ID		3675	928
HPRD ID		05431	00880
Ensembl ID		ENSG00000005884	ENSG00000010278
Uniprot IDs		A0A140VJM0 P26006	A0A087WU13 A6NNI4 B4DK09 G8JLH6 P21926
PDB IDs		Not available	6K4J 6RLO 6RLR 6Z1V 6Z20
GO Terms Enriched among Interactors		Integrin Binding Focal Adhesion Protease Binding Calcium-independent Cell-matrix Adhesion Cell Surface Cell Activation Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Endothelial Cell Migration Protein-folding Chaperone Binding Positive Regulation Of Cell Migration Cell Migration Leukocyte Activation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Motility Laminin Binding Protein Maturation Extracellular Space Regulation Of Cell Motility Regulation Of Locomotion External Side Of Plasma Membrane Cell Motility Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Fusion Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Cellular Response To Low-density Lipoprotein Particle Stimulus Cell-substrate Adhesion Response To Muscle Activity Positive Regulation Of Endocytosis Cardiac Muscle Cell Differentiation Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Biological Process Involved In Interaction With Symbiont Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Cell Differentiation Cellular Component Assembly Regulation Of Neuron Differentiation B Cell Activation Positive Regulation Of Transport Lymphocyte Activation Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cardiocyte Differentiation Cell Adhesion	Cell Surface Integrin Binding Membrane Plasma Membrane External Side Of Plasma Membrane System Process Integrin Complex Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Learning Or Memory Regulation Of Locomotion Developmental Process Cognition Cell-matrix Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Protein-containing Complex Binding Regulation Of Multicellular Organismal Process Regulation Of System Process Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Pyrimidine Nucleoside Transmembrane Transporter Activity Vascular Process In Circulatory System Focal Adhesion Import Into Cell Regulation Of Epithelial Cell Migration Neurotransmitter Reuptake Laminin Binding Cell Adhesion Cell-substrate Adhesion Positive Regulation Of Signaling Myoblast Fusion Involved In Skeletal Muscle Regeneration Integrin Alpha2-beta1 Complex Putrescine Transmembrane Transporter Activity Virus Receptor Activity Circulatory System Process Regulation Of Biological Quality Positive Regulation Of Protein Localization To Membrane Myoblast Fusion Cell Adhesion Mediated By Integrin Positive Regulation Of Signal Transduction Receptor Complex Wound Healing, Spreading Of Cells Neurotransmitter Uptake Response To Muscle Activity