ITGA3 and ADAM9

Number of citations of the paper that reports this interaction (PMID 15361064)
10

Data Source:
HPRD (in vitro)

		ITGA3	ADAM9
Gene Name		integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	ADAM metallopeptidase domain 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Growth Cone Filopodium Membrane Integrin Alpha3-beta1 Complex Receptor Complex Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Vesicular Exosome Invadopodium Membrane Cell Periphery Synaptic Membrane	Extracellular Space Cytoplasm Focal Adhesion Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Laminin Binding
	Biological Process	Neuron Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation Memory Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Response To Drug Skin Development Mesodermal Cell Differentiation Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Dendritic Spine Maintenance Renal Filtration	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Extracellular Matrix Disassembly Extracellular Matrix Organization Keratinocyte Differentiation Collagen Catabolic Process Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Response To Laminar Fluid Shear Stress Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis PMA-inducible Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		Laminin interactions Integrin cell surface interactions Basigin interactions Cell surface interactions at the vascular wall	Collagen degradation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 RABIF TIMP2 TSPAN4	9 interactors: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		3675	8754
HPRD ID		05431	04091
Ensembl ID		ENSG00000005884	ENSG00000168615
Uniprot IDs		P26006	Q13443
PDB IDs			1M1V
Enriched GO Terms of Interacting Partners?		Cell Activation Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Calcium-independent Cell-matrix Adhesion Cellular Component Assembly Cell Junction Assembly Leukocyte Activation Positive Regulation Of Cell Development Cell-cell Adhesion Mediated By Integrin Regulation Of Neuron Differentiation Positive Regulation Of Catalytic Activity System Development Regulation Of Cell Adhesion Extracellular Matrix Disassembly Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Metabolic Process Cell Adhesion Mediated By Integrin Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cell Adhesion Regulation Of Neurogenesis Multicellular Organismal Development Cardiocyte Differentiation Anatomical Structure Development Lymphocyte Activation Positive Regulation Of Neurogenesis Blood Coagulation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hemostasis Immune System Process B Cell Activation Cell-matrix Adhesion Response To Hormone Regulation Of Endocytosis Cardiac Muscle Tissue Development Muscle Structure Development Developmental Process Regulation Of Catalytic Activity Single Organismal Cell-cell Adhesion Neurogenesis Cell-substrate Adhesion Positive Regulation Of Hydrolase Activity Protein Maturation Striated Muscle Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Signaling Regulation Of Protein Complex Assembly Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Protein Catabolic Process Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Lipid Storage Positive Regulation Of Protein Oligomerization Positive Regulation Of Cellular Protein Metabolic Process Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Regulation Of Phosphorylation Cell-substrate Adhesion Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Response To Wounding Regulation Of Phosphorus Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phagocytosis Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Phosphorylation Regulation Of Lipid Catabolic Process Positive Regulation Of Cell Migration Regulation Of Lipid Storage Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Protein Modification Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?			aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Difference) ?			aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
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