ITGA3 and CD151

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (pull down, affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		ITGA3	CD151
Name		integrin subunit alpha 3	CD151 molecule (Raph blood group)
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Growth Cone Filopodium Membrane Neuromuscular Junction Integrin Alpha3-beta1 Complex Cell Projection Receptor Complex Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Excitatory Synapse Extracellular Exosome Anchoring Junction Cell Periphery Synaptic Membrane Glutamatergic Synapse Growth Cone Filopodium	Basement Membrane Cytosol Plasma Membrane Focal Adhesion Cell Surface Membrane
	Molecular Function	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Integrin Binding Protein Binding
	Biological Process	Neuron Migration System Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Heart Development Memory Response To Xenobiotic Stimulus Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Cell Differentiation Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Skin Development Mesodermal Cell Differentiation System Development Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Cell-cell Adhesion Postsynapse Organization Synaptic Membrane Adhesion Positive Regulation Of Protein Localization To Plasma Membrane	Cell Adhesion Cell Migration Positive Regulation Of Cell Migration T Cell Proliferation Wound Healing, Spreading Of Cells Positive Regulation Of Endocytosis
Pathways		Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling	Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly
Diseases		None	Nephropathy with pretibial epidermolysis bullosa and deafness
GWAS		No GWAS studies recorded	Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 )
Interacting Genes		16 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 LINC00632 RABIF TIMP2 TSPAN4	12 interacting genes: ARL13B BCL7A GRAMD1C ITGA3 ITGA6 ITGB1 KLRC1 MMP7 PTGFRN RNF128 TMEM139 TSPAN18
Entrez ID		3675	977
HPRD ID		05431	03763
Ensembl ID		ENSG00000005884	ENSG00000177697
Uniprot IDs		A0A140VJM0 P26006	P48509 Q6ZNZ0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Integrin Binding Focal Adhesion Protease Binding Calcium-independent Cell-matrix Adhesion Cell Surface Cell Activation Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Endothelial Cell Migration Protein-folding Chaperone Binding Positive Regulation Of Cell Migration Cell Migration Leukocyte Activation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Motility Laminin Binding Protein Maturation Extracellular Space Regulation Of Cell Motility Regulation Of Locomotion External Side Of Plasma Membrane Cell Motility Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Fusion Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Cellular Response To Low-density Lipoprotein Particle Stimulus Cell-substrate Adhesion Response To Muscle Activity Positive Regulation Of Endocytosis Cardiac Muscle Cell Differentiation Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Biological Process Involved In Interaction With Symbiont Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Cell Differentiation Cellular Component Assembly Regulation Of Neuron Differentiation B Cell Activation Positive Regulation Of Transport Lymphocyte Activation Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cardiocyte Differentiation Cell Adhesion	Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Complex Formation Of Radial Glial Scaffolds Cell-matrix Adhesion Integrin-mediated Signaling Pathway Mesodermal Cell Differentiation Laminin Binding Negative Regulation Of Rho Protein Signal Transduction Cell-substrate Adhesion Myoblast Fusion Fibronectin Binding Receptor Complex Syncytium Formation By Plasma Membrane Fusion Cell-cell Fusion Syncytium Formation Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Integrin Alpha6-beta4 Complex Myoblast Fate Specification Integrin Alpha7-beta1 Complex Inhibitory MHC Class Ib Receptor Activity Antibacterial Peptide Secretion Signaling Receptor Activity Cell Surface Negative Regulation Of Small GTPase Mediated Signal Transduction Synaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha9-beta1 Complex HLA-E Specific Inhibitory MHC Class Ib Receptor Activity External Side Of Plasma Membrane Positive Regulation Of GTPase Activity Growth Cone Filopodium Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Localization To Membrane Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation