LEP and STAT3

Number of citations of the paper that reports this interaction (PMID 12824284)
3

Data Source:
BioGRID (pull down)

		LEP	STAT3
Gene Name		leptin	signal transducer and activator of transcription 3 (acute-phase response factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	Hormone Activity Growth Factor Activity Peptide Hormone Receptor Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Response To Dietary Excess Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Fatty Acid Beta-oxidation Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Insulin Secretion Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Appetite Response To Insulin Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Bone Mineralization Involved In Bone Maturation Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Vasoconstriction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Leukocyte Tethering Or Rolling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Signaling by Leptin Incretin synthesis, secretion, and inactivation	Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		10 interactors: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 STAT3 UCN	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		3952	6774
HPRD ID		01249	00026
Ensembl ID		ENSG00000174697	ENSG00000168610
Uniprot IDs		A4D0Y8 P41159	K7ENL3 P40763
PDB IDs		1AX8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Feeding Behavior Response To Organic Substance Generation Of Precursor Metabolites And Energy Negative Regulation Of Cell Death Regulation Of Response To Food Regulation Of Carbohydrate Metabolic Process Regulation Of Appetite Regulation Of Cellular Ketone Metabolic Process Protein Activation Cascade Regulation Of Cytokine Production Regulation Of Glycolytic Process Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucose Homeostasis Response To Estrogen Secretion Transport Acute-phase Response Regulation Of Vasodilation Regulation Of Cell Death Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Cellular Metabolic Process Lipid Transport Signaling Lipid Localization Chemical Homeostasis Neurogenesis Negative Regulation Of Hormone Secretion Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Response To Hormone Acute Inflammatory Response Positive Regulation Of Tau-protein Kinase Activity Cortisol Secretion Regulation Of Neuronal Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Microglial Cell Proliferation Response To External Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?