LBR and MECP2

Number of citations of the paper that reports this interaction (PMID 19331822)
18

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		LBR	MECP2
Gene Name		lamin B receptor	methyl CpG binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Poly(A) RNA Binding Chromo Shadow Domain Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Cholesterol Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Glutamine Metabolic Process Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Pathogenesis Post-embryonic Development Dendrite Development Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Negative Regulation Of Histone Methylation Cardiolipin Metabolic Process Negative Regulation Of Histone Acetylation Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation
Pathways		Cholesterol biosynthesis Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS			Red blood cell traits ( 23446634)
Protein-Protein Interactions		11 interactors: AKAP8L CBX3 CBX5 FNBP4 HIST1H3A HIST2H4A LMNB1 MECP2 PRM1 SRPK1 YWHAG	17 interactors: DNMT1 GTF2B HDAC1 HIPK2 HIST2H3A HMGB1 LBR NCOR1 PRPF40A PRPF40B RNF4 SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1
Entrez ID		3930	4204
HPRD ID		02488	02050
Ensembl ID		ENSG00000143815	ENSG00000169057
Uniprot IDs		Q14739	D3YJ43 P51608 Q59FJ6
PDB IDs		2DIG	1QK9 3C2I
Enriched GO Terms of Interacting Partners?		Chromatin Silencing DNA Packaging Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic DNA Conformation Change Chromatin Organization DNA Replication-dependent Nucleosome Assembly Gene Silencing DNA Methylation On Cytosine Chromatin Silencing At RDNA Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Methylation DNA Modification DNA Metabolic Process Nucleosome Assembly Histone H4-K20 Demethylation Chromatin Assembly Nucleosome Organization Catecholamine Secretion Chromatin Modification Chromatin Assembly Or Disassembly Negative Regulation Of Megakaryocyte Differentiation Proprioception Protein-DNA Complex Assembly Regulation Of Synaptic Plasticity Chromatin Remodeling Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Sperm Chromatin Condensation Regulation Of RNA Metabolic Process Cardiolipin Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Respiratory Gaseous Exchange By Neurological System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuromuscular Process Controlling Posture Regulation Of Synaptic Transmission Regulation Of Respiratory System Process Regulation Of Gene Expression Glucocorticoid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Chromosome Organization Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding Cellular Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta
Tagcloud ?		absent antiserum b1 cardiomyocyte cast discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 libraries localize mabs muscular myocyte nuclei phage recognize rim spots	ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		absent antiserum b1 cardiomyocyte cast discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 libraries localize mabs muscular myocyte phage recognize rim spots	ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Intersection) ?		nuclei