LAMB3 and BMP1

Number of citations of the paper that reports this interaction (PMID 10806203)
37

Data Source:
HPRD (in vitro, in vivo)

		LAMB3	BMP1
Gene Name		laminin, beta 3	bone morphogenetic protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Laminin-5 Complex	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle
	Molecular Function	Structural Molecule Activity Protein Binding Protein Complex Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Brown Fat Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		5 interactors: BMP1 COL7A1 LAMA3 LAMC2 THBS1	14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		3914	649
HPRD ID		01032	00209
Ensembl ID		ENSG00000196878	ENSG00000168487
Uniprot IDs		Q13751	P13497
PDB IDs			3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Tissue Development Hemidesmosome Assembly Epidermis Development Endodermal Cell Differentiation Cell Adhesion Cell-substrate Junction Assembly Endoderm Formation Endoderm Development Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Formation Of Primary Germ Layer Anatomical Structure Development Anatomical Structure Morphogenesis Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Gastrulation Cartilage Development Developmental Process Cell Junction Assembly Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Negative Regulation Of Antigen Processing And Presentation Connective Tissue Development Regulation Of CGMP-mediated Signaling Negative Regulation Of Endopeptidase Activity Skeletal System Morphogenesis Negative Regulation Of Peptidase Activity Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Plasminogen Activation Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Positive Regulation Of Fibroblast Migration Protein O-linked Fucosylation Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Protein Processing Positive Regulation Of Macrophage Activation Regulation Of Endopeptidase Activity Cellular Response To Nitric Oxide Negative Regulation Of Hydrolase Activity Chronic Inflammatory Response Phagocytosis, Engulfment Regulation Of Fibrinolysis Regulation Of Protein Processing	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus
Tagcloud ?		besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Difference) ?		besides built c13orf18 ccl3 cish clustering comprising cytoreductive discriminators et fosb gadd45b granulocytes hrh4 id2 jak jak2v617f klf5 maff mutational pim1 signature socs2 socs3 stat supervised tagap thrombocythemia trib1	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Intersection) ?