LAMB3 and LAMC2

Number of citations: 0 (PubMedID 10964684)
Data Source: HPRD (in vivo)

		LAMB3	LAMC2
Name		laminin subunit beta 3	laminin subunit gamma 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Matrix	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Cell Adhesion Epidermis Development Cell Differentiation Endodermal Cell Differentiation Brown Fat Cell Differentiation	Cell Adhesion Positive Regulation Of Cell Population Proliferation Epidermis Development Positive Regulation Of Cell Migration
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055 )	Acne (severe) ( 30542056 ) Blood protein levels ( 30072576 ) Clozapine-induced agranulocytosis ( 25187353 ) HDL cholesterol ( 21347282 ) Low density lipoprotein cholesterol levels ( 32154731 ) Morning person ( 30696823 ) Systemic lupus erythematosus ( 21408207 )
Novel Interactors		None recorded	1 novel interactors: SCAP
Interacting Genes		6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		3914	3918
HPRD ID		01032	01031
Ensembl ID		ENSG00000196878	ENSG00000058085
Uniprot IDs		A0A0S2Z3R6 Q13751	Q13753
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Epidermis Development Endodermal Cell Differentiation Cell Adhesion Extracellular Region Collagen Type VII Trimer Developmental Process Extracellular Space Laminin-2 Complex Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Laminin-5 Complex Laminin-3 Complex Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Tissue Development Heparin Binding Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Hemidesmosome Assembly Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transforming Growth Factor Beta1 Production Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Fibrinogen Binding Hemidesmosome Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Complex Regulation Of Cell Migration Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Antigen Processing And Presentation Blood Coagulation, Fibrin Clot Formation Chronic Inflammatory Response Regulation Of Nitric Oxide Mediated Signal Transduction Cell Differentiation Endoplasmic Reticulum Lumen Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Fibrinolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of CGMP-mediated Signaling Proteoglycan Binding Protein Maturation Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Pattern Specification Process	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Binding Endodermal Cell Differentiation Collagen Type VII Trimer SREBP-SCAP Complex CSF1-CSF1R Complex Macrophage Colony-stimulating Factor Receptor Activity Response To Vitamin B3 Extracellular Region