LAMB3 and LAMA3

Number of citations of the paper that reports this interaction (PubMedID 7775432)
0

Data Source:
HPRD (in vitro)

		LAMB3	LAMA3
Description		laminin subunit beta 3	laminin subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Matrix	Extracellular Region Basement Membrane Laminin-3 Complex Laminin-5 Complex Endoplasmic Reticulum Adherens Junction Hemidesmosome Extracellular Matrix Extracellular Exosome
	Molecular Function	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Cell Adhesion Epidermis Development Cell Differentiation Endodermal Cell Differentiation Brown Fat Cell Differentiation	Cell Adhesion Epidermis Development Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs			Lanoteplase
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Laryngoonychocutaneous syndrome Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)	Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 22959728) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1	7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1
Entrez ID		3914	3909
HPRD ID		01032	02883
Ensembl ID		ENSG00000196878	ENSG00000053747
Uniprot IDs		A0A0S2Z3R6 Q13751	A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Epidermis Development Endodermal Cell Differentiation Cell Adhesion Extracellular Region Collagen Type VII Trimer Developmental Process Extracellular Space Laminin-2 Complex Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Laminin-5 Complex Laminin-3 Complex Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Tissue Development Heparin Binding Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Hemidesmosome Assembly Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transforming Growth Factor Beta1 Production Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Fibrinogen Binding Hemidesmosome Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Complex Regulation Of Cell Migration Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Antigen Processing And Presentation Blood Coagulation, Fibrin Clot Formation Chronic Inflammatory Response Regulation Of Nitric Oxide Mediated Signal Transduction Cell Differentiation Endoplasmic Reticulum Lumen Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Fibrinolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of CGMP-mediated Signaling Proteoglycan Binding Protein Maturation Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Pattern Specification Process	Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Extracellular Matrix Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Fibrinolysis Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Maturation Cell Migration Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Cell Motility Peptidase Activity Proteolysis Schaffer Collateral - CA1 Synapse Blood Coagulation Coagulation Hemostasis Serine-type Peptidase Activity Laminin-5 Complex Regulation Of Wound Healing Cell Surface Positive Regulation Of Fibrinolysis Cellular Developmental Process Prevention Of Polyspermy Regulation Of Response To Wounding Serine Protease Inhibitor Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of Plasminogen Activation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Antigen Binding Leading Edge Membrane Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Fertilization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Cyclin-dependent Protein Kinase Activity Plasminogen Activation Beta-catenin Destruction Complex Gamma-catenin Binding
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