KRT17 and EVL

		KRT17	EVL
Description		keratin 17	Enah/Vasp-like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Cell Periphery	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Growth Epithelial Cell Differentiation Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS			Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		12 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 NEIL3 SNAPIN TRIM69 ZDHHC17	36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		3872	51466
HPRD ID		01019	10942
Ensembl ID		ENSG00000128422	ENSG00000196405
Uniprot IDs		Q04695 Q14666	A0A024R6K5 A0A2D1PGY7 Q9UI08
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Ruffle Assembly Cellular Response To Gamma Radiation Intermediate Filament Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Multivesicular Body, Internal Vesicle Lumen Response To Gamma Radiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Late Endosome To Lysosome Transport MCM Complex Binding Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Size Golgi Membrane Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of ERK1 And ERK2 Cascade Shc-EGFR Complex Cellular Response To Ionizing Radiation GTPase Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Insulin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Golgi Apparatus Regulation Of MiRNA Metabolic Process Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ruffle Membrane Positive Regulation Of Cold-induced Thermogenesis	Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway
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