RHOA and TIAM1

Number of citations of the paper that reports this interaction (PubMedID 32203420)
0

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		RHOA	TIAM1
Description		ras homolog family member A	TIAM Rac1 associated GEF 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Membrane Lamellipodium Cell Junction Dendrite Midbody Secretory Granule Membrane Vesicle Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Neuron Migration Kidney Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Alpha-beta T Cell Lineage Commitment Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Formation Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Cell Adhesion Cell-matrix Adhesion Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Skeletal Muscle Tissue Development Negative Regulation Of Cell-substrate Adhesion Regulation Of Neuron Projection Development Cell Migration Substantia Nigra Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Actin Cytoskeleton Organization Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Stress Fiber Assembly Apical Junction Assembly Beta Selection Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Positive Regulation Of Alpha-beta T Cell Differentiation Negative Chemotaxis Cell Division Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Bone Trabecula Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Negative Regulation Of Oxidative Phosphorylation Motor Neuron Apoptotic Process Endothelial Tube Lumen Extension Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cleavage Furrow Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of T Cell Migration Negative Regulation Of Motor Neuron Apoptotic Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation
Pathways		GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOC GTPase cycle	NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 28714974 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)
Interacting Genes		124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 BCR BIRC2 BMAL1 CAV1 CEBPA CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 LUC7L2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPOR2 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SNCA SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3	86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793
Entrez ID		387	7074
HPRD ID		01323	02820
Ensembl ID		ENSG00000067560	ENSG00000156299
Uniprot IDs		A0A024R324 A0A7I2YQV1 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0	A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009
PDB IDs		1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V 6V6M 6V6U 6V6V 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 7QSC 7QTM 7WZA 7WZC 8BNT 8FC7 8FC9 8FCB 8FPW 8FPX 8GI3 8GI6 8JVJ 8T1C 9AX5	2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction GTPase Activator Activity Guanyl-nucleotide Exchange Factor Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Cytosol Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Rho Protein Signal Transduction Small GTPase Binding Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Cytoplasm Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Cell Migration Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoskeleton Organization Regulation Of Actin Filament Organization Cell Projection Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Organelle Organization Cell Motility Regulation Of Stress Fiber Assembly Positive Regulation Of Small GTPase Mediated Signal Transduction Anchoring Junction Regulation Of GTPase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Inhibitor Activity Cell Projection Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction	Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly
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