RHOA and ARHGEF12

Number of citations of the paper that reports this interaction (PMID 11373293)
28

Data Source:
HPRD (in vivo, in vitro)

		RHOA	ARHGEF12
Gene Name		ras homolog family member A	Rho guanine nucleotide exchange factor (GEF) 12
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Viral Process Substantia Nigra Development Actin Cytoskeleton Organization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Cytokinesis Regulation Of Osteoblast Proliferation Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Trabecula Morphogenesis Mitotic Spindle Assembly Skeletal Muscle Satellite Cell Migration	G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Signaling by GPCR Axon guidance Axonal growth stimulation SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Rho GTPase cycle EPHA-mediated growth cone collapse Axonal growth inhibition (RHOA activation) PI3K/AKT activation G beta:gamma signalling through PI3Kgamma EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse TGFBR2 MSI Frameshift Mutants in Cancer Signalling by NGF TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer p75NTR regulates axonogenesis G-protein beta:gamma signalling Loss of Function of SMAD2/3 in Cancer Semaphorin interactions TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer p75 NTR receptor-mediated signalling TGFBR1 KD Mutants in Cancer NGF signalling via TRKA from the plasma membrane Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling GPCR downstream signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF Signaling by Rho GTPases GPVI-mediated activation cascade Platelet activation, signaling and aggregation PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		90 interactors: AKAP13 ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 BCR BIRC2 CAV1 CIT CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DOCK7 DVL2 FAM65B FLNA GMIP GNA12 GNB2L1 HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 MCF2 MCF2L MPRIP NET1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PPP1R12A PRKACA PRKCA PRKCZ RABAC1 RAP1GDS1 RASGRF1 RHPN1 RHPN2 RIPK4 ROCK1 RPN2 RTKN SH3BP1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 TEC TGFBR1 TGM2 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3	13 interactors: ABCA1 CD44 CUL3 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 RHOA TEC
Entrez ID		387	23365
HPRD ID		01323	09207
Ensembl ID		ENSG00000067560	ENSG00000196914
Uniprot IDs		P61586 Q9BVT0	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rho GTPase Activity Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Signaling Positive Regulation Of Ras GTPase Activity Regulation Of GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rho Protein Signal Transduction Response To Stimulus Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Apoptotic Signaling Pathway Cell Death Death Regulation Of Cellular Process Regulation Of Apoptotic Process Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Cell Death Locomotion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Rac GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Neuron Projection Development	Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Signaling Cell Communication Regulation Of Cell Motility Anatomical Structure Morphogenesis Tissue Morphogenesis Regulation Of Ras Protein Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stimulus Positive Regulation Of Cytokinesis Regulation Of Cell Shape Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Neuron Projection Development Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Wound Healing Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Response To Wounding Positive Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Ossification Involved In Bone Maturation
Tagcloud ?		1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Difference) ?		1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic undetectable vasculature
Tagcloud (Intersection) ?		rho rhoa