RHOA and PRKCA

Number of citations of the paper that reports this interaction (PubMedID 11284700)
0

Data Source:
HPRD (in vivo)

		RHOA	PRKCA
Description		ras homolog family member A	protein kinase C alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Membrane Lamellipodium Cell Junction Dendrite Midbody Secretory Granule Membrane Vesicle Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex Alphav-beta3 Integrin-PKCalpha Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin Binding Protein Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Diacylglycerol Binding Histone H3T6 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Neuron Migration Kidney Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Alpha-beta T Cell Lineage Commitment Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Formation Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Cell Adhesion Cell-matrix Adhesion Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Skeletal Muscle Tissue Development Negative Regulation Of Cell-substrate Adhesion Regulation Of Neuron Projection Development Cell Migration Substantia Nigra Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Actin Cytoskeleton Organization Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Stress Fiber Assembly Apical Junction Assembly Beta Selection Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Positive Regulation Of Alpha-beta T Cell Differentiation Negative Chemotaxis Cell Division Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Bone Trabecula Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Negative Regulation Of Oxidative Phosphorylation Motor Neuron Apoptotic Process Endothelial Tube Lumen Extension Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Satellite Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cleavage Furrow Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of T Cell Migration Negative Regulation Of Motor Neuron Apoptotic Process	Response To Reactive Oxygen Species Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Chromatin Remodeling Protein Phosphorylation Apoptotic Process Mitotic Nuclear Membrane Disassembly Cell Adhesion Learning Or Memory Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Translation Central Nervous System Neuron Axonogenesis Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Peptide Hormone Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Exocytosis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Transport Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Renal Sodium Ion Absorption Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Dense Core Granule Biogenesis
Pathways		GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOC GTPase cycle	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Guanosine-5'-Diphosphate	Phosphatidyl serine Vitamin E Tamoxifen Staurosporine Dequalinium Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Benzoyl peroxide Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 28714974 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Body composition traits ( 30026463) Brugada syndrome ( 35210625) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Daytime nap ( 33568662) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Haemorrhoidal disease ( 33888516) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 30012220 27577874 27659466) QT interval ( 24952745 29213071 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)
Interacting Genes		124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 BCR BIRC2 BMAL1 CAV1 CEBPA CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 LUC7L2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPOR2 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SNCA SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3	230 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NHERF1 NHERF2 NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN1 PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STMN1 STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		387	5578
HPRD ID		01323	01498
Ensembl ID		ENSG00000067560	ENSG00000154229
Uniprot IDs		A0A024R324 A0A7I2YQV1 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0	J3KRN5 L7RSM7 P17252 Q7Z727
PDB IDs		1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V 6V6M 6V6U 6V6V 7G80 7G81 7G82 7G83 7G84 7G85 7G86 7G87 7G88 7G89 7G8A 7G8B 7G8C 7G8D 7G8E 7G8F 7G8G 7G8H 7G8I 7G8J 7G8K 7G8L 7G8M 7G8N 7G8O 7G8P 7G8Q 7G8R 7G8S 7G8T 7G8U 7G8V 7G8W 7G8X 7G8Y 7G8Z 7G90 7G91 7G92 7G93 7G94 7G95 7G96 7G97 7G98 7G99 7G9A 7G9B 7G9C 7G9D 7G9E 7G9F 7G9G 7G9H 7G9I 7G9J 7QSC 7QTM 7WZA 7WZC 8BNT 8FC7 8FC9 8FCB 8FPW 8FPX 8GI3 8GI6 8JVJ 8T1C 9AX5	2ELI 3IW4 4DNL 4RA4 8U37 8UAK
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction GTPase Activator Activity Guanyl-nucleotide Exchange Factor Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Cytosol Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Rho Protein Signal Transduction Small GTPase Binding Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Cytoplasm Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Cell Migration Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoskeleton Organization Regulation Of Actin Filament Organization Cell Projection Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Organelle Organization Cell Motility Regulation Of Stress Fiber Assembly Positive Regulation Of Small GTPase Mediated Signal Transduction Anchoring Junction Regulation Of GTPase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction Rho GDP-dissociation Inhibitor Activity Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Inhibitor Activity Cell Projection Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction	Regulation Of Biological Quality Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Cell Communication Regulation Of System Process Regulation Of Developmental Process Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Transport Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Cell Development Regulation Of Membrane Potential Cellular Developmental Process Regulation Of Programmed Cell Death Negative Regulation Of Signaling Calmodulin Binding Focal Adhesion Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Blood Circulation Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Development Regulation Of Vesicle-mediated Transport Protein Kinase Binding Regulation Of Protein Metabolic Process Cell Differentiation Glutamatergic Synapse Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Dendritic Spine
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