RHOA and ARHGEF2

Number of citations of the paper that reports this interaction (PMID 9857026)
55

Data Source:
HPRD (in vitro)

		RHOA	ARHGEF2
Gene Name		ras homolog family member A	Rho/Rac guanine nucleotide exchange factor (GEF) 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Tight Junction Focal Adhesion Cytoplasmic Membrane-bounded Vesicle Vesicle Ruffle Membrane Neuronal Cell Body Dendritic Shaft Protein Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Rho GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Viral Process Substantia Nigra Development Actin Cytoskeleton Organization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Cytokinesis Regulation Of Osteoblast Proliferation Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Trabecula Morphogenesis Mitotic Spindle Assembly Skeletal Muscle Satellite Cell Migration	Establishment Of Mitotic Spindle Orientation Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Mitotic Nuclear Division Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac GTPase Activity Regulation Of Rho Protein Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Pathways		Loss of Function of TGFBR2 in Cancer Signaling by GPCR Axon guidance Axonal growth stimulation SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Rho GTPase cycle EPHA-mediated growth cone collapse Axonal growth inhibition (RHOA activation) PI3K/AKT activation G beta:gamma signalling through PI3Kgamma EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse TGFBR2 MSI Frameshift Mutants in Cancer Signalling by NGF TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer p75NTR regulates axonogenesis G-protein beta:gamma signalling Loss of Function of SMAD2/3 in Cancer Semaphorin interactions TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer p75 NTR receptor-mediated signalling TGFBR1 KD Mutants in Cancer NGF signalling via TRKA from the plasma membrane Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling GPCR downstream signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF Signaling by Rho GTPases GPVI-mediated activation cascade Platelet activation, signaling and aggregation PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		90 interactors: AKAP13 ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 BCR BIRC2 CAV1 CIT CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DOCK7 DVL2 FAM65B FLNA GMIP GNA12 GNB2L1 HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 MCF2 MCF2L MPRIP NET1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PPP1R12A PRKACA PRKCA PRKCZ RABAC1 RAP1GDS1 RASGRF1 RHPN1 RHPN2 RIPK4 ROCK1 RPN2 RTKN SH3BP1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 TEC TGFBR1 TGM2 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3	9 interactors: CGN PAK1 RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAZ
Entrez ID		387	9181
HPRD ID		01323	10458
Ensembl ID		ENSG00000067560	ENSG00000116584
Uniprot IDs		P61586 Q9BVT0	Q92974
PDB IDs		1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rho GTPase Activity Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Signaling Positive Regulation Of Ras GTPase Activity Regulation Of GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rho Protein Signal Transduction Response To Stimulus Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Apoptotic Signaling Pathway Cell Death Death Regulation Of Cellular Process Regulation Of Apoptotic Process Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Cell Death Locomotion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Rac GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Neuron Projection Development	Positive Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Stress Fiber Assembly Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrion Organization Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Organelle Organization Apoptotic Process Cellular Response To Organic Substance Signal Transduction Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Cell Death Death Cell Differentiation Signaling Cell Communication Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hyperosmotic Response Wound Healing Response To Growth Factor Intrinsic Apoptotic Signaling Pathway Cellular Protein Localization Platelet Activation Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Motility Response To Organic Substance Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Locomotion
Tagcloud ?		1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase	bona cd centered crohn disregulated driven exerted fide genic gwass hebp1 interactor italian meta nod2 nonetheless nonselected nsf predisposition preferential prioritize protozoa protozoan shaping signatures snps strongest subject vamp3
Tagcloud (Difference) ?		1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase	bona cd centered crohn disregulated driven exerted fide genic gwass hebp1 interactor italian meta nod2 nonetheless nonselected nsf predisposition preferential prioritize protozoa protozoan shaping signatures snps strongest subject vamp3
Tagcloud (Intersection) ?