KRTAP10-1 and ECE1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRTAP10-1	ECE1
Gene Name		keratin associated protein 10-1	endothelin converting enzyme 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Keratin Filament	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		Endopeptidase Activity Metalloendopeptidase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process		Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		73 interactors: ADAMTSL4 AEN AVPI1 BAHD1 BCL6B C19orf66 CARD9 CATSPER1 CBX2 CHIC2 CHRD CREB5 CXCL16 DAAM2 DHX57 DKK1 DOCK2 ECE1 FAM76B GLRX3 HOXA1 HPCAL1 HSD3B7 KRTAP10-3 KRTAP12-1 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E MAPKBP1 MEOX2 MOBP NOTCH2NL NPDC1 NR4A1 OTX1 PID1 PIN1 POM121L8P PRM2 PRPF31 PVRL2 RSPO2 SLC23A1 SLC6A20 SPATA8 SPRY1 SPRY2 TULP3 ZBTB24 ZNF101 ZNF124 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF785 ZSCAN12 ZSCAN26	8 interactors: AGT CALCA CLK2 EDN1 KNG1 KRTAP10-1 KRTAP10-5 MYOC
Entrez ID		386677	1889
HPRD ID		11184	02690
Ensembl ID		ENSG00000215455	ENSG00000117298
Uniprot IDs		P60331	B4DKB2 P42892
PDB IDs			3DWB
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Biosynthetic Process Lung Growth Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Regulation Of Neurotrophin TRK Receptor Signaling Pathway Limb Development Embryonic Morphogenesis Pattern Specification Process Developmental Process Embryonic Neurocranium Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Epithelium Development Cellular Process Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Multicellular Organismal Development Respiratory Tube Development Anterior/posterior Pattern Specification Organ Development Lung Morphogenesis Respiratory System Development Embryonic Limb Morphogenesis Tissue Development Cell Differentiation Negative Regulation Of Ras GTPase Activity Limb Morphogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Tube Development Embryo Development Branch Elongation Of An Epithelium Inner Ear Morphogenesis	Regulation Of Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Muscle System Process Regulation Of Neurological System Process Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Circulation Artery Smooth Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Renal System Process Tonic Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Vascular Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Urine Volume Negative Regulation Of Tissue Remodeling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Homeostasis Muscle Contraction Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Differentiation Chemical Homeostasis Positive Regulation Of Vasodilation Vasoconstriction Negative Regulation Of Cellular Metabolic Process Cellular Calcium Ion Homeostasis Positive Regulation Of Oxidoreductase Activity Calcium Ion Homeostasis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Secretion Aging Positive Regulation Of Cell Migration Regulation Of Vasodilation Positive Regulation Of Cell Motility
Tagcloud ?			5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype
Tagcloud (Difference) ?			5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype
Tagcloud (Intersection) ?