MAT2B and YTHDF3

		MAT2B	YTHDF3
Description		methionine adenosyltransferase 2 non-catalytic beta subunit	YTH N6-methyladenosine RNA binding protein F3
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GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process	Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Organelle Assembly Regulation Of Trophoblast Cell Migration
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Myocardial infarction ( 26708285) Schizophrenia ( 33169155) Smoking behaviour (cigarettes smoked per day) ( 30679032) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: APP CEBPA FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	17 interacting genes: ALG13 ANKHD1 CPSF7 CTTN DMRTB1 EXOSC5 FAF1 LARP4 NMD3 PRRC2B QKI RBFOX2 RBM22 RPS21 SF1 SNRPA ZDHHC17
Entrez ID		27430	253943
HPRD ID		05701	08106
Ensembl ID		ENSG00000038274	ENSG00000185728
Uniprot IDs		A0A140VJP2 Q9NZL9	A0A024R7W5 A0A087WY31 B4DPX9 Q7Z739 Q8NA80
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	6ZOT 8BS5 8BS6
Enriched GO Terms of Interacting Partners?			RNA Binding Nucleic Acid Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome MRNA Binding Cytosolic Small Ribosomal Subunit Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleic Acid Metabolic Process Spliceosomal Complex Gamma-glutamyl-peptidase Activity Regulation Of RNA Splicing Internal N(7)-methylguanine-containing RNA Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Methionine Adenosyltransferase Regulator Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Macromolecule Metabolic Process
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