MAT2B and CNIH4

		MAT2B	CNIH4
Description		methionine adenosyltransferase 2 non-catalytic beta subunit	cornichon family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Signaling Receptor Binding Protein Binding CCR5 Chemokine Receptor Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Major depressive disorder ( 21042317) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		11 interacting genes: APP CEBPA FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	4 interacting genes: GLP1R GPR25 TMEM14B TSNARE1
Entrez ID		27430	29097
HPRD ID		05701	13709
Ensembl ID		ENSG00000038274	ENSG00000143771
Uniprot IDs		A0A140VJP2 Q9NZL9	A6NLH6 Q9P003
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?			Glucagon-like Peptide 1 Receptor Activity Methionine Adenosyltransferase Regulator Activity Glucagon Receptor Activity Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process Response To Psychosocial Stress Post-translational Protein Targeting To Membrane, Translocation
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