MAT2B and GABRA1

		MAT2B	GABRA1
Description		methionine adenosyltransferase 2 non-catalytic beta subunit	gamma-aminobutyric acid type A receptor subunit alpha1
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GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA Receptor Complex GABA-A Receptor Complex
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Methylation Ub-specific processing proteases	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Topiramate Etomidate Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Picrotoxin Methohexital Chlordiazepoxide Chlordiazepoxide Amoxapine Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Progabide Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Zaleplon Methoxyflurane Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Methyprylon Thiamylal Halothane Halothane Phenobarbital Desflurane Zopiclone Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Clomethiazole Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Age at first sexual intercourse ( 34211149) Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Gait speed in old age ( 28077804)
Interacting Genes		11 interacting genes: APP CEBPA FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	6 interacting genes: DRD4 P2RX2 PPP3CA PRKCD PRKCG UBQLN1
Entrez ID		27430	2554
HPRD ID		05701	00662
Ensembl ID		ENSG00000038274	ENSG00000022355
Uniprot IDs		A0A140VJP2 Q9NZL9	A8K177 P14867
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	6CDU 6D1S 6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7PBD 7PBZ 7PC0 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG 9H9E
Enriched GO Terms of Interacting Partners?			Regulation Of Transport Multicellular Organismal Response To Stress Regulation Of Postsynaptic Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Angiotensin Skeletal Muscle Fiber Development Regulation Of Calcium Ion Transport Myotube Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Cell Communication Positive Regulation Of Transport Response To Stress Positive Regulation Of Signaling Regulation Of Endocytosis Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Excitatory Postsynaptic Potential Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Negative Regulation Of Angiotensin-activated Signaling Pathway Enzyme Binding Striated Muscle Cell Development Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Methionine Adenosyltransferase Regulator Activity Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Neurotransmitter Secretion Regulation Of Membrane Potential Regulation Of Calcium-mediated Signaling Muscle Cell Development Positive Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sphingomyelin Catabolic Process Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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