LMO4 and PER2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LMO4	PER2
Description		LIM domain only 4	period circadian regulator 2
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GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm Cry-Per Complex
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Tissue Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Developmental Process Regulation Of Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Neural Retina Development Glycogen Biosynthetic Process Gluconeogenesis Chromatin Remodeling Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis
Pathways			Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs
Diseases			Familial advanced sleep phase syndrome
GWAS		Academic attainment (English) ( 33594131) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 27354352) Eosinophil count ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Chronotype ( 26955885 27494321 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321)
Interacting Genes		131 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG QRICH1 RBAK RBBP8 RBPMS RCN1 REDIC1 RLIM RNF8 ROPN1 RPS6KA6 RSPH6A SAXO4 SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675	20 interacting genes: BHLHE41 CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A
Entrez ID		8543	8864
HPRD ID		09122	04575
Ensembl ID		ENSG00000143013	ENSG00000132326
Uniprot IDs		P61968	O15055
PDB IDs		9F5B	6OF7 8D7M 8D7N 8D7O
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Structural Molecule Activity Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Organelle Organization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Cytoskeleton Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Epithelial Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Centrosome Cycle Positive Regulation Of RNA Metabolic Process Microtubule-based Process Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity BHLH Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity RNA Polymerase II Transcription Regulator Complex	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Entrainment Of Circadian Clock Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription E-box Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Kinase Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucocorticoid Secretion Response To Radiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA Damage Response Response To Blue Light Regulation Of Primary Metabolic Process Cellular Response To Radiation Photoreceptor Activity DNA-binding Transcription Factor Binding Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Thymocyte Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Regulation Of Glucose Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Circadian Rhythm Regulation Of RNA Biosynthetic Process
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