LMO4 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		LMO4	RBBP8
Description		LIM domain only 4	RB binding protein 8, endonuclease
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GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Tissue Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Developmental Process Regulation Of Cell Activation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways			HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS		Academic attainment (English) ( 33594131) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Breast cancer ( 27354352) Eosinophil count ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		131 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG QRICH1 RBAK RBBP8 RBPMS RCN1 REDIC1 RLIM RNF8 ROPN1 RPS6KA6 RSPH6A SAXO4 SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		8543	5932
HPRD ID		09122	04990
Ensembl ID		ENSG00000143013	ENSG00000101773
Uniprot IDs		P61968	Q99708
PDB IDs		9F5B	1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Structural Molecule Activity Supramolecular Fiber Organization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Organelle Organization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Cytoskeleton Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Epithelial Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Centrosome Cycle Positive Regulation Of RNA Metabolic Process Microtubule-based Process Microtubule Cytoskeleton Organization DNA-binding Transcription Factor Activity BHLH Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity RNA Polymerase II Transcription Regulator Complex	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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