MAPK8IP1 and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 10490659)
36

Data Source:
HPRD (in vivo)

		MAPK8IP1	MAP3K10
Description		mitogen-activated protein kinase 8 interacting protein 1	mitogen-activated protein kinase kinase kinase 10
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Dendrite Mitochondrial Membrane Neuron Projection Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction JNK Cascade Vesicle-mediated Transport Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways
Drugs		Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Anthralin	Fostamatinib
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting glucose ( 34059833) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		28 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 RSPH1 SNCA TIAM1 VPS26C VRK2	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		9479	4294
HPRD ID		05223	02533
Ensembl ID		ENSG00000121653	ENSG00000130758
Uniprot IDs		Q6NUQ9 Q9UQF2	Q02779
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ 7NYK 7NYL 7NYM 7NYN 7NYO 7NZB 8RPP	2RF0
Enriched GO Terms of Interacting Partners?		JNK Cascade Intracellular Signaling Cassette MAPK Cascade MAP Kinase Kinase Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Kinesin Binding Signal Transduction MAP Kinase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Growth Factor Protein Autophosphorylation Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of JNK Cascade Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Enzyme Binding Axon Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of JNK Cascade JUN Kinase Binding	MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration
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