MAPK8IP1 and RECQL5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAPK8IP1	RECQL5
Description		mitogen-activated protein kinase 8 interacting protein 1	RecQ like helicase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Dendrite Mitochondrial Membrane Neuron Projection Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction JNK Cascade Vesicle-mediated Transport Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs		Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Anthralin
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting glucose ( 34059833) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		28 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 RSPH1 SNCA TIAM1 VPS26C VRK2	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		9479	9400
HPRD ID		05223	04806
Ensembl ID		ENSG00000121653	ENSG00000108469
Uniprot IDs		Q6NUQ9 Q9UQF2	B3KQK2 O94762
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ 7NYK 7NYL 7NYM 7NYN 7NYO 7NZB 8RPP	4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		JNK Cascade Intracellular Signaling Cassette MAPK Cascade MAP Kinase Kinase Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Kinesin Binding Signal Transduction MAP Kinase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Growth Factor Protein Autophosphorylation Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of JNK Cascade Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Enzyme Binding Axon Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of JNK Cascade JUN Kinase Binding	Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair
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