MAPK8IP1

Description		mitogen-activated protein kinase 8 interacting protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Dendrite Mitochondrial Membrane Neuron Projection Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction JNK Cascade Vesicle-mediated Transport Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs		Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Anthralin
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting glucose ( 34059833) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: EXOSC8
Interacting Genes		28 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 RSPH1 SNCA TIAM1 VPS26C VRK2
Entrez ID		9479
HPRD ID		05223
Ensembl ID		ENSG00000121653
Uniprot IDs		Q6NUQ9 Q9UQF2
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ 7NYK 7NYL 7NYM 7NYN 7NYO 7NZB 8RPP
Enriched GO Terms of Interacting Partners?		JNK Cascade Intracellular Signaling Cassette MAPK Cascade MAP Kinase Kinase Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Kinesin Binding Signal Transduction MAP Kinase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Growth Factor Protein Autophosphorylation Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of JNK Cascade Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Enzyme Binding Axon Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of JNK Cascade JUN Kinase Binding
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