KIF5C and KIF5A

Number of citations of the paper that reports this interaction (PubMedID 38334954)
77

Data Source:
BioGRID (cross-linking study)
HPRD (in vivo)

		KIF5C	KIF5A
Description		kinesin family member 5C	kinesin family member 5A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Dendrite Dendrite Cytoplasm Ciliary Rootlet Cell Projection Neuron Projection Neuronal Cell Body Axonal Growth Cone GABA-ergic Synapse Postsynaptic Cytosol Distal Axon Axon Cytoplasm	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Axon Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity ATP Hydrolysis Activity Apolipoprotein Receptor Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding
	Biological Process	Organelle Organization Microtubule-based Movement Axon Guidance Motor Neuron Axon Guidance Intracellular MRNA Localization Synaptic Vesicle Transport MRNA Transport Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Insulin processing	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chronotype ( 30696823) Mild age-related type 2 diabetes ( 34737425)	Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 18794853 24449572) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		10 interacting genes: CSNK2A1 ITSN1 KIF5A KLC1 KLC3 MEOX2 NCOA2 PCNT SNAPIN YWHAG	24 interacting genes: BACH1 CREBBP DSCAM DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 NRIP1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1
Entrez ID		3800	3798
HPRD ID		18371	09108
Ensembl ID		ENSG00000168280	ENSG00000155980
Uniprot IDs		O60282 Q59GB8	J3KNA1 Q12840
PDB IDs			4UXT 4UXY 4UY0
Enriched GO Terms of Interacting Partners?		Kinesin Binding Kinesin Complex Ciliary Rootlet Axo-dendritic Transport Microtubule Microtubule-based Movement Microtubule-based Process Retrograde Axonal Transport Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Microtubule-based Transport Negative Regulation Of Translational Initiation Intracellular Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Cytoskeletal Motor Activity Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Positive Regulation Of Late Endosome To Lysosome Transport Axonal Transport Neuron Projection Cellular Localization Establishment Of Localization In Cell Organelle Transport Along Microtubule Clathrin-dependent Synaptic Vesicle Endocytosis Protein Localization To Vacuole Vesicle-mediated Transport In Synapse Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Vesicle Localization Protein Kinase C Inhibitor Activity Cellular Response To Thyroglobulin Triiodothyronine Intracellular Protein Localization Cytoplasm Vesicle Localization Positive Regulation Of Caveolin-mediated Endocytosis Protein Transport Positive Regulation Of Aggrephagy Retrograde Neuronal Dense Core Vesicle Transport Somite Specification Positive Regulation Of Intracellular Transport Response To Thyroglobulin Triiodothyronine Terminal Button Organization Sperm Mitochondrial Sheath Assembly Protein-containing Complex Disassembly Intracellular Protein Transport Vacuolar Transport	Cytoplasm Ciliary Rootlet Kinesin Complex Microtubule Neuron Projection Axo-dendritic Transport Postsynaptic Cytosol Intracellular Signal Transduction Establishment Of Vesicle Localization Microtubule Binding Vesicle Localization Transcription Coregulator Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Axon Cytoplasm Transport Along Microtubule Axonal Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Transcription Corepressor Activity Microtubule-based Transport Dendritic Transport Positive Regulation Of GTPase Activity Proline-rich Region Binding Plus-end-directed Microtubule Motor Activity Regulation Of Modification Of Synaptic Structure Retrograde Axonal Transport Positive Regulation Of Cell Communication Rhythmic Process Positive Regulation Of Signaling Signal Transduction Establishment Of Organelle Localization Positive Regulation Of Hydrolase Activity Cell Projection Organization Transcription Coactivator Activity Dendrite Cytoplasm Positive Regulation Of Cellular Component Biogenesis Hippo Signaling Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Nervous System Development Centrosome Localization Regulation Of GTPase Activity Response To Progesterone Regulation Of Cellular Component Organization Synaptic Vesicle Transport Regulation Of Protein Localization
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