KIF5C and NCOA2

Number of citations of the paper that reports this interaction (PubMedID 11986669)
0

Data Source:
HPRD (two hybrid, in vivo)

		KIF5C	NCOA2
Description		kinesin family member 5C	nuclear receptor coactivator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Dendrite Dendrite Cytoplasm Ciliary Rootlet Cell Projection Neuron Projection Neuronal Cell Body Axonal Growth Cone GABA-ergic Synapse Postsynaptic Cytosol Distal Axon Axon Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity ATP Hydrolysis Activity Apolipoprotein Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Protein Domain Specific Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Organelle Organization Microtubule-based Movement Axon Guidance Motor Neuron Axon Guidance Intracellular MRNA Localization Synaptic Vesicle Transport MRNA Transport Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Circadian Rhythm Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Response To Progesterone Cellular Response To Hormone Stimulus Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Locomotor Rhythm Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Adipose Tissue Development
Pathways		Insulin processing	BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Diethylstilbestrol Genistein Metribolone 17-METHYL-17-ALPHA-DIHYDROEQUILENIN din-6-yl)phenol TO-901317 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 2-chloro-5-nitro-N-phenylbenzamide dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Tributyltin 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chronotype ( 30696823) Mild age-related type 2 diabetes ( 34737425)	Apolipoprotein A1 levels ( 32203549) Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) Height ( 33713608) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Multiple sclerosis ( 24076602) Non-small cell lung cancer ( 23144319) Plateletcrit ( 32888494) QT interval ( 24952745) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775) Systemic lupus erythematosus ( 33536424)
Interacting Genes		10 interacting genes: CSNK2A1 ITSN1 KIF5A KLC1 KLC3 MEOX2 NCOA2 PCNT SNAPIN YWHAG	67 interacting genes: ACTN2 AHR ANKRD11 AR ARNT BRCA1 CARM1 CCND3 CCNT1 CDK4 CFAP298 CREBBP CTNNB1 DDX17 DDX5 DLX2 DLX5 EID1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FLII FOS GMEB1 H3-4 H4C16 HIF1A HNF4A JUN KIF5A KIF5B KIF5C MAGEA11 MEF2C NKX2-1 NR1I2 NR2F1 NR3C1 NR4A1 OPN1LW PIAS3 PML PPARA PPARD PPARG PPFIA1 PPFIA4 PRMT1 PSMB9 RARA RORA RXRA SLC30A9 SMARCE1 SRCAP STAT6 SUMO1 TAF9 THRA THRB TP53 TXNRD2 VDR YWHAH
Entrez ID		3800	10499
HPRD ID		18371	09066
Ensembl ID		ENSG00000168280	ENSG00000140396
Uniprot IDs		O60282 Q59GB8	B4DPW8 Q15596
PDB IDs			1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6HL1 6KKB 6KKE 6KNU 6KNV 6KNW 6LB4 6LB5 6LB6 6LIT 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI 6VC2 6VIF 7A77 7A78 7A79 7APO 7B88 7B9O 7BK4 7D42 7JHD 7JYD 7JYE 7KCO 7NEL 7NFB 7NKE 7OFI 7OFK 7PDQ 7PDT 7RAE 7RAF 7RKE 7SFO 7T2X 7TT8 7UW2 7UW4 7VUE 7W3P 7W3Q 7WLX 7WMG 7WMH 7WMJ 7WML 7WMN 7WMO 7YMK 8C1L 8DAF 8EV1 8EV2 8F8M 8GL7 8P9X 8PP0 8PWD 8PWE 8PWF 8PWM 8PZ6 8PZ7 8PZ8 8PZ9 8PZB 8VKZ 9EZ1 9EZ2 9GY8 9GYA 9GYC 9GYJ 9GYK
Enriched GO Terms of Interacting Partners?		Kinesin Binding Kinesin Complex Ciliary Rootlet Axo-dendritic Transport Microtubule Microtubule-based Movement Microtubule-based Process Retrograde Axonal Transport Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Microtubule-based Transport Negative Regulation Of Translational Initiation Intracellular Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Cytoskeletal Motor Activity Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Positive Regulation Of Late Endosome To Lysosome Transport Axonal Transport Neuron Projection Cellular Localization Establishment Of Localization In Cell Organelle Transport Along Microtubule Clathrin-dependent Synaptic Vesicle Endocytosis Protein Localization To Vacuole Vesicle-mediated Transport In Synapse Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Vesicle Localization Protein Kinase C Inhibitor Activity Cellular Response To Thyroglobulin Triiodothyronine Intracellular Protein Localization Cytoplasm Vesicle Localization Positive Regulation Of Caveolin-mediated Endocytosis Protein Transport Positive Regulation Of Aggrephagy Retrograde Neuronal Dense Core Vesicle Transport Somite Specification Positive Regulation Of Intracellular Transport Response To Thyroglobulin Triiodothyronine Terminal Button Organization Sperm Mitochondrial Sheath Assembly Protein-containing Complex Disassembly Intracellular Protein Transport Vacuolar Transport	Nuclear Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Chromatin Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Cis-regulatory Region Binding Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus RNA Polymerase II Transcription Regulator Complex Regulation Of MiRNA Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex
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