SERPINA3 and KLK3

Number of citations of the paper that reports this interaction (PMID 9261179)
16

Data Source:
HPRD (in vitro, in vivo)

		SERPINA3	KLK3
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	kallikrein-related peptidase 3
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Nucleus Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium	Proteolysis Negative Regulation Of Angiogenesis Cellular Protein Metabolic Process
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Body mass index ( 23669352)	PCA3 expression level ( 23555189) Prostate cancer ( 18264097) Prostate-specific antigen levels ( 21160077 23269536)
Protein-Protein Interactions		25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1	14 interactors: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		12	354
HPRD ID		00120	01461
Ensembl ID		ENSG00000196136	ENSG00000142515
Uniprot IDs		G3V5I3 P01011	P07288 Q546G3
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA	1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response	Platelet Degranulation Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Platelet Activation Blood Coagulation Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Exocytosis Response To Wounding Acute-phase Response Negative Regulation Of Catalytic Activity Reproductive Process Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Protein Metabolic Process Acute Inflammatory Response Regulation Of Catalytic Activity Extracellular Matrix Disassembly Secretion Cell Activation Negative Regulation Of Cellular Metabolic Process Tissue Homeostasis Multicellular Organismal Homeostasis Female Pregnancy Response To Methanol Nipple Sheath Formation Mammary Gland Bud Elongation Vesicle-mediated Transport Endoderm Development Extracellular Matrix Organization Extracellular Structure Organization Maintenance Of Mitochondrion Location Erythropoietin-mediated Signaling Pathway Response To Triglyceride Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Inflammatory Response Response To Platinum Ion Mononuclear Cell Migration Hemolysis By Symbiont Of Host Erythrocytes
Tagcloud ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	ags aire autoimmune autoimmunity chrna1 copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
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