SERPINA3 and CTRC

Number of citations of the paper that reports this interaction (PMID 8718849)
7

Data Source:
HPRD (in vivo)

		SERPINA3	CTRC
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	chymotrypsin C (caldecrin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity
	Biological Process	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium	Proteolysis
Pathways
Drugs
Diseases
GWAS		Body mass index ( 23669352)
Protein-Protein Interactions		25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1	8 interactors: KRTAP10-3 KRTAP10-7 NEDD8 PHKG1 SERPINA3 SPINK1 ST13 UBC
Entrez ID		12	11330
HPRD ID		00120	03242
Ensembl ID		ENSG00000196136	ENSG00000162438
Uniprot IDs		G3V5I3 P01011	Q99895
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA	4H4F
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response	Glycogen Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Polysaccharide Metabolic Process Regulation Of Proteolysis Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Carbohydrate Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Protein Refolding Pathogenesis Hexose Metabolic Process Negative Regulation Of Calcium Ion Import Chaperone Cofactor-dependent Protein Refolding Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Serine-type Endopeptidase Activity Protein Neddylation Negative Regulation Of Serine-type Peptidase Activity Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Generation Of Precursor Metabolites And Energy Regulation Of Store-operated Calcium Entry Glycogen Catabolic Process Protein Refolding Epithelial Structure Maintenance Polysaccharide Catabolic Process Regulation Of Calcium Ion Import Notch Receptor Processing
Tagcloud ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1
Tagcloud (Difference) ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1
Tagcloud (Intersection) ?