SERPINA3 and ADAMTS4

Number of citations of the paper that reports this interaction (PubMedID 16099106)
0

Data Source:
HPRD (two hybrid)

		SERPINA3	ADAMTS4
Description		serpin family A member 3	ADAM metallopeptidase with thrombospondin type 1 motif 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium
Pathways		Platelet degranulation Neutrophil degranulation	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 27182965 31361310 31619474) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		12	9507
HPRD ID		00120	04853
Ensembl ID		ENSG00000196136	ENSG00000158859
Uniprot IDs		P01011	O75173
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing
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