SERPINA3 and ADH1B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SERPINA3	ADH1B
Name		serpin family A member 3	alcohol dehydrogenase 1B (class I), beta polypeptide
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine	Retinoid Metabolic Process Lipid Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Platelet degranulation Neutrophil degranulation	Ethanol oxidation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin
GWAS		Blood protein levels ( 30072576 ) Body mass index ( 23669352 ) Prostate-specific antigen levels ( 28139693 ) Serum total protein levels ( 29403010 )	Adult body size ( 32376654 ) Alcohol consumption ( 31358974 28937693 23743675 ) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404 ) Alcohol consumption (drinks per week) ( 30643258 30679032 28485404 31959922 ) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841 ) Alcohol consumption in current drinkers ( 28937693 ) Alcohol dependence ( 33290381 24166409 31090166 28714907 23456092 31591379 22004471 ) Alcohol dependence (desire to cut drinking) ( 31090166 ) Alcohol dependence (tolerance) ( 31090166 ) Alcohol dependence symptom count ( 31090166 ) Alcohol use disorder ( 30940813 ) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876 ) Alcohol use disorder (dependence and problematic use scores) ( 30336701 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Bitter alcoholic beverage consumption ( 31046077 ) Blood urea nitrogen levels ( 31152163 ) Esophageal cancer ( 19698717 ) Esophageal cancer (alcohol interaction) ( 22960999 ) Gout ( 33832965 ) Gout vs asymptomatic hyperuricemia ( 33832965 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Initial pursuit acceleration ( 29064472 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung cancer ( 28604730 ) Maximum habitual alcohol consumption ( 31151762 ) Metabolite levels ( 23823483 ) Oral cavity and pharyngeal cancer ( 27749845 21437268 ) Oral cavity cancer ( 27749845 ) Oropharynx cancer ( 27749845 ) Problematic alcohol use ( 32451486 ) Regular attendance at a pub or social club ( 29970889 ) Relative fat intake ( 32393786 ) Relative protein intake ( 32393786 ) Reticulocyte count ( 32888494 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3
Entrez ID		12	125
HPRD ID		00120	00065
Ensembl ID		ENSG00000196136	ENSG00000196616
Uniprot IDs		P01011	D6RHZ6 P00325 V9HW50
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K	1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
GO Terms Enriched among Interactors		Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath	Molecular Adaptor Activity Response To Peptide Response To Cytokine Negative Regulation Of Translation In Response To Oxidative Stress Protein Homodimerization Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Component Organization Cortical Microtubule Plus-end IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Positive Regulation Of Macrophage Tolerance Induction Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cobalt Ion Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Localization To Chromosome, Telomeric Region Ubiquitin-like Protein Ligase Activity Negative Regulation Of Translation Regulation Of Cellular Component Organization Negative Regulation Of Translational Initiation In Response To Stress Oncogene-induced Cell Senescence Negative Regulation Of Growth Positive Regulation Of Apoptotic Process Involved In Morphogenesis PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Translational Elongation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Gastrulation Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding Toll Signaling Pathway Rhythmic Process Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Microtubule Nucleation Protein Tyrosine Kinase Inhibitor Activity Positive Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Translation In Response To Stress Positive Regulation Of Mitochondrial Depolarization Regulation Of Translational Initiation In Response To Stress SUMO Binding Astral Microtubule Organization Regulation Of Translational Elongation Regulation Of Golgi To Plasma Membrane Protein Transport Homeostatic Process Protein Heterodimerization Activity Negative Regulation Of Cytokine Production Positive Regulation Of Membrane Depolarization