SERPINA3 and ADH1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SERPINA3	ADH1B
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	alcohol dehydrogenase 1B (class I), beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle	Cytosol
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Alcohol Dehydrogenase Activity, Zinc-dependent Zinc Ion Binding
	Biological Process	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium	Ethanol Oxidation Xenobiotic Metabolic Process Small Molecule Metabolic Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs			NADH Ethanol Fomepizole Nicotinamide-Adenine-Dinucleotide N-Benzylformamide 4-Iodopyrazole 2\'-Monophosphoadenosine 5\'-Diphosphoribose Cyclohexanol Glycerol N-Heptylformamide
Diseases
GWAS		Body mass index ( 23669352)	Alcohol consumption ( 23743675) Alcohol dependence ( 23456092 22004471) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) Upper aerodigestive tract cancers ( 21437268)
Protein-Protein Interactions		25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1	5 interactors: GNB2L1 IRAK3 PDE4DIP PML SERPINA3
Entrez ID		12	125
HPRD ID		00120	00065
Ensembl ID		ENSG00000196136
Uniprot IDs		G3V5I3 P01011	A8MYN5 P00325
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA	1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response	Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Peptidase Activity Negative Regulation Of Translation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Translation In Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Positive Regulation Of CAMP Catabolic Process Negative Regulation Of Cell Growth Regulation Of Ion Homeostasis Regulation Of Catalytic Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity PML Body Organization Protein Processing Negative Regulation Of Growth Negative Regulation Of Telomere Maintenance Via Telomerase Response To Virus Regulation Of Translation Negative Regulation Of Oxidative Stress-induced Neuron Death Common-partner SMAD Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Phosphorylation Rhythmic Process SMAD Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Translation In Response To Stress Negative Regulation Of Protein Phosphorylation
Tagcloud ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant
Tagcloud (Difference) ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	acetaldehyde acetate alcohol alcoholism aldehyde aldh aldh2 allelotypes asians aucs carrying causal combinatorial dehydrogenase east ethanol facial flushing fsbf genotypic han heterozygotes homozygotes ingesting peak pulse resultant
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