BCL6 and HDAC1

Number of citations of the paper that reports this interaction (PubMedID 9753732)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		BCL6	HDAC1
Description		BCL6 transcription repressor	histone deacetylase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus Paraspeckles	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol NuRD Complex Transcription Repressor Complex Protein-containing Complex Neuronal Cell Body Sin3-type Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Enzyme Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Plasma Cell Differentiation Immune System Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of Type 2 Immune Response Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response DNA Damage Response Cell-matrix Adhesion Rho Protein Signal Transduction Spermatogenesis Intracellular Protein Localization Cell Population Proliferation Pyramidal Neuron Differentiation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Heterochromatin Formation Negative Regulation Of Mast Cell Cytokine Production Mononuclear Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response B Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation T-helper 2 Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Cell Motility Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Negative Regulation Of Plasma Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Hippocampus Development Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Heterochromatin Formation Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Transcription Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Valproic acid Arsenic trioxide Decitabine Zinc Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Fingolimod Mocetinostat Entinostat Abexinostat Abexinostat Givinostat Pyroxamide Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hairy-cell leukemia
GWAS		Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Appendicular lean mass ( 33097823) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)
Interacting Genes		91 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PAK1 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SNCA SP1 SPI1 SPMIP2 SPMIP4 SPMIP6 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1	187 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CEBPA CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HMGB1 HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 JUP KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD4 MDM2 MECOM MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 PARP1 PCNA PEX14 PHB1 PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA PTOV1 RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBC UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76
Entrez ID		604	3065
HPRD ID		00180	03143
Ensembl ID		ENSG00000113916	ENSG00000116478
Uniprot IDs		B5B0A5 P41182	Q13547 Q6IT96
PDB IDs		1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TBT 6TCJ 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU 7BDE 7GUD 7GUE 7GUF 7GUG 7GUH 7GUI 7GUJ 7GUK 7GUL 7GUM 7GUN 7GUO 7GUP 7GUQ 7GUR 7GUS 7GUT 7GUU 7GUV 7GUW 7GUX 7GUY 7GUZ 7GV0 7GV1 7GV2 7GV3 7GV4 7GV5 7GV6 7GV7 7GV8 7GV9 7GVA 7GVB 7GVC 7GVD 7GVE 7GVF 7GVG 7GVH 7GVI 7GVJ 7GVK 7GVL 7GVM 7GVN 7GVO 7GVP 7GVQ 7GVR 7GVS 7GVT 7GVU 7GVV 7GVW 7GVX 7GVY 7GVZ 7GW0 7GW1 7GW2 7GW3 7GW4 7GW5 7GW6 7GW7 7GW8 7GW9 7GWA 7GWB 7GWC 7GWD 7GWE 7GWF 7GWG 7GWH 7GWI 7GWJ 7GWK 7GWL 7GWM 7GWN 7GWO 7GWP 7GWQ 7GWR 7GWS 7GWT 7GWU 7GWV 7GWW 7GWX 7GWY 7GWZ 7GX0 7GX1 7GX2 7GX3 7GX4 7GX5 7GX6 7GX7 7GX8 7GX9 7GXA 7GXB 7GXC 7GXD 7GXE 7GXF 7GXG 7GXH 7GXI 7GXJ 7GXK 7GXL 7GXM 7GXN 7GXO 7GXP 7GXQ 7GXR 7GXS 7GXT 7GXU 7GXV 7GXW 7GXX 7GXY 7GXZ 7GY0 7GY1 7GY2 7GY3 7LWE 7LWF 7LWG 7LZQ 7LZR 7LZS 7OKD 7OKE 7OKF 7OKG 7OKH 7OKI 7OKJ 7OKK 7OKL 7OKM 7Q7R 7Q7S 7Q7T 7Q7U 7Q7V 7QK0 7RUW 7RUX 7RUY 7RUZ 7RV0 7RV1 7RV2 7RV3 7RV4 7RV5 7RV6 7RV7 7RV8 7RV9 7T0S 7T0T 7T0U 7ZWN 7ZWO 7ZWP 7ZWQ 7ZWR 7ZWS 7ZWT 7ZWU 7ZWV 7ZWW 7ZWX 7ZWY 7ZWZ 8AS9 8C78	4BKX 5ICN 6Z2J 6Z2K 7AO8 7AO9 7AOA 7SME 8VOJ 8VPQ 8VRT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Transcription Repressor Complex DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Transcription Corepressor Activity Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Histone Deacetylase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Protein Lysine Deacetylase Activity Transcription Corepressor Binding Positive Regulation Of Metabolic Process Transcription Coactivator Binding Chromatin Organization Negative Regulation Of Developmental Process	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process DNA Binding Transcription Corepressor Activity Histone Deacetylase Binding Chromatin Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Sin3-type Complex Sequence-specific DNA Binding
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