BCL6 and TP53BP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BCL6	TP53BP1
Name		BCL6 transcription repressor	tumor protein p53 binding protein 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus Paraspeckles	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	P53 Binding DNA Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Telomeric DNA Binding Histone Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-modified Histone Reader Activity Histone H4K20me2 Reader Activity Histone Reader Activity Histone H4K20me Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Plasma Cell Differentiation Immune System Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of Type 2 Immune Response Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response DNA Damage Response Cell-matrix Adhesion Rho Protein Signal Transduction Spermatogenesis Intracellular Protein Localization Cell Population Proliferation Pyramidal Neuron Differentiation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Heterochromatin Formation Negative Regulation Of Mast Cell Cytokine Production Mononuclear Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response B Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation T-helper 2 Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Cell Motility Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Negative Regulation Of Plasma Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	DNA Damage Checkpoint Signaling DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Diseases		Hairy-cell leukemia	None
GWAS		Adverse response to drug ( 30420678 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 31361310 ) Allergic sensitization ( 23817571 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 ) B cell non-Hodgkin lymphoma ( 23749188 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Blood urea nitrogen levels ( 29403010 ) Glucose homeostasis traits ( 25524916 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 23534349 ) Pulmonary function (smoking interaction) ( 23284291 ) Renal function-related traits (BUN) ( 22797727 ) Selective IgA deficiency ( 27723758 ) Self-reported allergy ( 23817569 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 25760438 )	Antibody level in response to infection ( 25758998 ) Apolipoprotein A1 levels ( 32203549 ) Cardiometabolic and hematological traits ( 27668658 ) Eosinophil count ( 32888494 ) HDL cholesterol levels ( 32203549 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643 ) Liver volume ( 34128465 ) Lung cancer in ever smokers ( 28604730 ) Mean corpuscular volume ( 32888494 ) Triglyceride levels ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 27036123 )
Interacting Genes		91 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PAK1 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SNCA SP1 SPI1 SPMIP2 SPMIP4 SPMIP6 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1	60 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CEBPA CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4C1 H4C14 H4C16 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SPOP SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14
Entrez ID		604	7158
HPRD ID		00180	05569
Ensembl ID		ENSG00000113916	ENSG00000067369
Uniprot IDs		B5B0A5 P41182	A6NNK5 Q12888
PDB IDs		1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TBT 6TCJ 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU 7BDE 7GUD 7GUE 7GUF 7GUG 7GUH 7GUI 7GUJ 7GUK 7GUL 7GUM 7GUN 7GUO 7GUP 7GUQ 7GUR 7GUS 7GUT 7GUU 7GUV 7GUW 7GUX 7GUY 7GUZ 7GV0 7GV1 7GV2 7GV3 7GV4 7GV5 7GV6 7GV7 7GV8 7GV9 7GVA 7GVB 7GVC 7GVD 7GVE 7GVF 7GVG 7GVH 7GVI 7GVJ 7GVK 7GVL 7GVM 7GVN 7GVO 7GVP 7GVQ 7GVR 7GVS 7GVT 7GVU 7GVV 7GVW 7GVX 7GVY 7GVZ 7GW0 7GW1 7GW2 7GW3 7GW4 7GW5 7GW6 7GW7 7GW8 7GW9 7GWA 7GWB 7GWC 7GWD 7GWE 7GWF 7GWG 7GWH 7GWI 7GWJ 7GWK 7GWL 7GWM 7GWN 7GWO 7GWP 7GWQ 7GWR 7GWS 7GWT 7GWU 7GWV 7GWW 7GWX 7GWY 7GWZ 7GX0 7GX1 7GX2 7GX3 7GX4 7GX5 7GX6 7GX7 7GX8 7GX9 7GXA 7GXB 7GXC 7GXD 7GXE 7GXF 7GXG 7GXH 7GXI 7GXJ 7GXK 7GXL 7GXM 7GXN 7GXO 7GXP 7GXQ 7GXR 7GXS 7GXT 7GXU 7GXV 7GXW 7GXX 7GXY 7GXZ 7GY0 7GY1 7GY2 7GY3 7LWE 7LWF 7LWG 7LZQ 7LZR 7LZS 7OKD 7OKE 7OKF 7OKG 7OKH 7OKI 7OKJ 7OKK 7OKL 7OKM 7Q7R 7Q7S 7Q7T 7Q7U 7Q7V 7QK0 7RUW 7RUX 7RUY 7RUZ 7RV0 7RV1 7RV2 7RV3 7RV4 7RV5 7RV6 7RV7 7RV8 7RV9 7T0S 7T0T 7T0U 7ZWN 7ZWO 7ZWP 7ZWQ 7ZWR 7ZWS 7ZWT 7ZWU 7ZWV 7ZWW 7ZWX 7ZWY 7ZWZ 8AS9 8C78	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP 7LIN 7LIO 7YQK 8EOM 8F0W 8HKW 8SVG 8SVH 8SVI 8SVJ 8SWJ 8T2D 8U4U 9CKJ
GO Terms Enriched among Interactors		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Transcription Repressor Complex DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Transcription Corepressor Activity Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Histone Deacetylase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Protein Lysine Deacetylase Activity Transcription Corepressor Binding Positive Regulation Of Metabolic Process Transcription Coactivator Binding Chromatin Organization Negative Regulation Of Developmental Process	Response To Ionizing Radiation Chromatin Organization Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Response Chromosome, Telomeric Region Regulation Of Cell Cycle Process Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Chromatin Remodeling Negative Regulation Of Cell Cycle DNA Repair Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Cellular Response To Radiation DNA Binding Response To Radiation DNA Damage Checkpoint Signaling Regulation Of DNA Recombination Cellular Response To Ionizing Radiation Protein Localization To Chromosome Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Telomere Organization DNA Recombination Nucleus Transcription Regulator Complex Site Of Double-strand Break Protein-containing Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Regulation Of Cell Cycle G2/M Phase Transition Response To X-ray Regulation Of Macromolecule Metabolic Process Response To Gamma Radiation Replication Fork DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Signal Transduction By P53 Class Mediator